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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0204727,
umls-concept:C0205314,
umls-concept:C0205409,
umls-concept:C0679058,
umls-concept:C0679622,
umls-concept:C0971466,
umls-concept:C1283195,
umls-concept:C1423527,
umls-concept:C1547699,
umls-concept:C1880022,
umls-concept:C2700640
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-3-27
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pubmed:databankReference |
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pubmed:abstractText |
A novel human KRAB (Krüppel associated box) type zinc finger protein encoding gene, ZNF463, was obtained by mRNA differential display and RACE. It consists of 1904 nucleotides and encodes a protein of 463 amino acids with an amino-terminal KRAB domain and 12 carboxy-terminal C2H2 zinc finger units. The gene is mapped to chromosome 19q13.3 approximately 4 by FISH. As from Northern blot analysis ZNF463 is only expressed in testis, RT-PCR indicates that ZNF463 is expressed more highly in normal fertile adults than in fetus and azoospermic patients suggesting that it may play a role in human spermatogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-3002
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pubmed:author |
pubmed-author:AgerLL,
pubmed-author:FanTT,
pubmed-author:HuangMM,
pubmed-author:HuangXX,
pubmed-author:MilunskyAA,
pubmed-author:QiuWW,
pubmed-author:WuHH,
pubmed-author:XiaQQ,
pubmed-author:XiaoCC,
pubmed-author:YangJJ,
pubmed-author:ZhangGG,
pubmed-author:ZhangSS
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
1518
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
190-3
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11267678-Adult,
pubmed-meshheading:11267678-Amino Acid Sequence,
pubmed-meshheading:11267678-Base Sequence,
pubmed-meshheading:11267678-Carrier Proteins,
pubmed-meshheading:11267678-Chromosome Mapping,
pubmed-meshheading:11267678-Chromosomes, Human, Pair 19,
pubmed-meshheading:11267678-DNA, Complementary,
pubmed-meshheading:11267678-DNA-Binding Proteins,
pubmed-meshheading:11267678-Gene Expression Profiling,
pubmed-meshheading:11267678-Humans,
pubmed-meshheading:11267678-In Situ Hybridization, Fluorescence,
pubmed-meshheading:11267678-Male,
pubmed-meshheading:11267678-Molecular Sequence Data,
pubmed-meshheading:11267678-Neoplasm Proteins,
pubmed-meshheading:11267678-Oligospermia,
pubmed-meshheading:11267678-Spermatogenesis,
pubmed-meshheading:11267678-Testis,
pubmed-meshheading:11267678-Zinc Fingers
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pubmed:year |
2001
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pubmed:articleTitle |
Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463.
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pubmed:affiliation |
Department of Medical Genetics, First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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