Human G cells express the calcium-sensing receptor and respond to extracellular calcium by releasing gastrin. However, the receptor on G cells is insensitive to serum calcium levels. We investigated whether this is a result of differential regulation of signaling pathways compared with parathyroid or calcitonin cells.
Department of Physiology, Faculty of Medicine, 2146 Health Sciences Mall, University of British Columbia, Vancouver V6T 1Z3, Canada. ambuchan@interchange.ubc.ca