|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-3-26
|
|
pubmed:abstractText |
Potent and selective EP3 receptor ligands were found by making a library using solid-support chemistry. These compounds can be obtained by a Suzuki coupling reaction of a solid-supported benzyl bromide using various boronic acids. The yields obtained for this reaction were in the range of 24-95% of arylmethyl cinnamic acid 1 after cleavage from the Wang resin.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
12
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
747-9
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11266183-Cinnamates,
pubmed-meshheading:11266183-Combinatorial Chemistry Techniques,
pubmed-meshheading:11266183-Humans,
pubmed-meshheading:11266183-Ligands,
pubmed-meshheading:11266183-Molecular Structure,
pubmed-meshheading:11266183-Receptors, Prostaglandin E,
pubmed-meshheading:11266183-Receptors, Prostaglandin E, EP3 Subtype,
pubmed-meshheading:11266183-Structure-Activity Relationship
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.
|
|
pubmed:affiliation |
Merck Frosst Canada & Co., Pointe-Claire, Dorval, Québec. helene_juteau@merck.com
|
|
pubmed:publicationType |
Journal Article
|
