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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-3-26
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pubmed:abstractText |
Novel pyranosyl analogues of SB-219383 have been synthesised to elucidate the structure-activity relationships around the pyran ring. Analogues with highly potent stereoselective and bacterioselective inhibition of bacterial tyrosyl tRNA synthetase have been identified. A major reduction in the overall polarity of the molecule can be tolerated without loss of the nanomolar level of inhibition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
715-8
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pubmed:meshHeading |
pubmed-meshheading:11266176-Bacterial Proteins,
pubmed-meshheading:11266176-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:11266176-Crystallography, X-Ray,
pubmed-meshheading:11266176-Enzyme Inhibitors,
pubmed-meshheading:11266176-Furans,
pubmed-meshheading:11266176-Molecular Conformation,
pubmed-meshheading:11266176-Molecular Structure,
pubmed-meshheading:11266176-Pyrans,
pubmed-meshheading:11266176-Staphylococcus aureus,
pubmed-meshheading:11266176-Tyrosine-tRNA Ligase
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pubmed:year |
2001
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pubmed:articleTitle |
Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.
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pubmed:affiliation |
GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, UK. pam_brown-1@sbphrd.com
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pubmed:publicationType |
Journal Article
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