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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-3-26
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pubmed:abstractText |
Delta-mediated Notch signaling controls cell fate decisions during invertebrate and murine development. However, in the human, functional roles for Delta have yet to be described. This study reports the characterization of Delta-1 and Delta-4 in the human. Human Delta-4 was found to be expressed in a wide range of adult and fetal tissues, including sites of hematopoiesis. Subsets of immature hematopoietic cells, along with stromal and endothelial cells that support hematopoiesis, were shown to express Notch and both Delta-1 and Delta-4. Soluble forms of human Delta-1 (h Delta-1) and h Delta-4 proteins were able to augment the proliferation of primitive human hematopoietic progenitors in vitro. Intravenous transplantation of treated cultures into immune-deficient mice revealed that h Delta-1 is capable of expanding pluripotent human hematopoietic repopulating cells detected in vivo. This study provides the first evidence for a role of Delta ligands as a mitogenic regulator of primitive hematopoietic cells in the human. (Blood. 2001;97:1960-1967)
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DLL4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NOTCH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NOTCH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Notch1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Notch2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Notch1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Notch2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/delta protein
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1960-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11264159-Adult,
pubmed-meshheading:11264159-Amino Acid Sequence,
pubmed-meshheading:11264159-Animals,
pubmed-meshheading:11264159-Blood Proteins,
pubmed-meshheading:11264159-Cell Differentiation,
pubmed-meshheading:11264159-Cell Division,
pubmed-meshheading:11264159-Cells, Cultured,
pubmed-meshheading:11264159-Fetal Blood,
pubmed-meshheading:11264159-Gene Expression Regulation, Developmental,
pubmed-meshheading:11264159-Graft Survival,
pubmed-meshheading:11264159-Growth Substances,
pubmed-meshheading:11264159-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11264159-Hematopoietic Stem Cells,
pubmed-meshheading:11264159-Humans,
pubmed-meshheading:11264159-Infant, Newborn,
pubmed-meshheading:11264159-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11264159-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11264159-Membrane Proteins,
pubmed-meshheading:11264159-Mice,
pubmed-meshheading:11264159-Mice, Inbred NOD,
pubmed-meshheading:11264159-Mice, SCID,
pubmed-meshheading:11264159-Mitosis,
pubmed-meshheading:11264159-Molecular Sequence Data,
pubmed-meshheading:11264159-Receptor, Notch1,
pubmed-meshheading:11264159-Receptor, Notch2,
pubmed-meshheading:11264159-Receptors, Cell Surface,
pubmed-meshheading:11264159-Recombinant Fusion Proteins,
pubmed-meshheading:11264159-Sequence Alignment,
pubmed-meshheading:11264159-Sequence Homology, Amino Acid,
pubmed-meshheading:11264159-Severe Combined Immunodeficiency,
pubmed-meshheading:11264159-Signal Transduction,
pubmed-meshheading:11264159-Solubility,
pubmed-meshheading:11264159-Transcription Factors,
pubmed-meshheading:11264159-Transplantation, Heterologous
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pubmed:year |
2001
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pubmed:articleTitle |
Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells.
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pubmed:affiliation |
Developmental Stem Cell Biology, The John P. Robarts Research Institute, London, ON, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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