|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2001-3-26
|
|
pubmed:abstractText |
A novel route to epoxysorbicillinol as well as dimers of sorbicillin is reported. The synthesis is-in principle-amenable to enantioselectivity. The key step is an oxidative dearomatization to produce a stable and highly malleable p-quinol intermediate, which undergoes a highly diastereoselective epoxidation.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1523-7060
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
22
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
905-8
|
|
pubmed:dateRevised |
2011-3-23
|
|
pubmed:meshHeading |
pubmed-meshheading:11263912-Cyclohexanones,
pubmed-meshheading:11263912-Dimerization,
pubmed-meshheading:11263912-Epoxy Compounds,
pubmed-meshheading:11263912-Indicators and Reagents,
pubmed-meshheading:11263912-Models, Molecular,
pubmed-meshheading:11263912-Molecular Conformation,
pubmed-meshheading:11263912-Molecular Structure,
pubmed-meshheading:11263912-Oxidation-Reduction,
pubmed-meshheading:11263912-Stereoisomerism,
pubmed-meshheading:11263912-Structure-Activity Relationship
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Synthesis of (+/-)-epoxysorbicillinol using a novel cyclohexa-2,5-dienone with synthetic applications to other sorbicillin derivatives.
|
|
pubmed:affiliation |
Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, USA. pettus@chem.ucsb.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
