| pubmed-article:11262408 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11262408 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11262408 | lifeskim:mentions | umls-concept:C1519726 | lld:lifeskim |
| pubmed-article:11262408 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:11262408 | pubmed:dateCreated | 2001-5-30 | lld:pubmed |
| pubmed-article:11262408 | pubmed:abstractText | Gab-1 is a multiple docking protein that is tyrosine phosphorylated by receptor tyrosine kinases such as c-Met, hepatocyte growth factor/scatter factor receptor, and epidermal growth factor receptor. We have now demonstrated that cell-cell adhesion also induces marked tyrosine phosphorylation of Gab-1 and that disruption of cell-cell adhesion results in its dephosphorylation. An anti-E-cadherin antibody decreased cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1, whereas the expression of E-cadherin specifically induced tyrosine phosphorylation of Gab-1. A relatively selective inhibitor of Src family kinases reduced cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1, whereas expression of a dominant-negative mutant of Csk increased it. Disruption of cell-cell adhesion, which reduced tyrosine phosphorylation of Gab-1, also reduced the activation of mitogen-activated protein kinase and Akt in response to cell-cell adhesion. These results indicate that E-cadherin-mediated cell-cell adhesion induces tyrosine phosphorylation by a Src family kinase of Gab-1, thereby regulating the activation of Ras/MAP kinase and phosphatidylinositol 3-kinase/Akt cascades. | lld:pubmed |
| pubmed-article:11262408 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11262408 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11262408 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11262408 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11262408 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11262408 | pubmed:author | pubmed-author:TakaiYY | lld:pubmed |
| pubmed-article:11262408 | pubmed:author | pubmed-author:NakanishiHH | lld:pubmed |
| pubmed-article:11262408 | pubmed:author | pubmed-author:KodamaAA | lld:pubmed |
| pubmed-article:11262408 | pubmed:author | pubmed-author:TachibanaKK | lld:pubmed |
| pubmed-article:11262408 | pubmed:author | pubmed-author:ShinoharaMM | lld:pubmed |
| pubmed-article:11262408 | pubmed:author | pubmed-author:FukuharaAA | lld:pubmed |
| pubmed-article:11262408 | pubmed:author | pubmed-author:MatozakiTT | lld:pubmed |
| pubmed-article:11262408 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11262408 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11262408 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11262408 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11262408 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11262408 | pubmed:pagination | 18941-6 | lld:pubmed |
| pubmed-article:11262408 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11262408 | pubmed:meshHeading | pubmed-meshheading:11262408... | lld:pubmed |
| pubmed-article:11262408 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11262408 | pubmed:articleTitle | Roles of cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1. | lld:pubmed |
| pubmed-article:11262408 | pubmed:affiliation | Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, 2-2 Yamada-oka, Suita 565-0871, Japan. | lld:pubmed |
| pubmed-article:11262408 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11262408 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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