Source:http://linkedlifedata.com/resource/pubmed/id/11262207
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2001-3-23
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| pubmed:abstractText |
The usefulness of testing for IgG avidity in association with Toxoplasma gondii was evaluated in a US reference laboratory. European investigators have reported that high-avidity IgG toxoplasma antibodies exclude acute infection in the preceding 3 months. In this US study, 125 serum samples taken from 125 pregnant women in the first trimester were chosen retrospectively, because either the IgM or differential agglutination (AC/HS) test in the Toxoplasma serologic profile suggested or was equivocal for a recently acquired infection. Of 93 (74.4%) serum samples with either positive or equivocal results in the IgM ELISA, 52 (55.9%) had high-avidity antibodies, which suggests that the infection probably was acquired before gestation. Of 87 (69.6%) serum samples with an acute or equivocal result in the AC/HS test, 35 (40.2%) had high-avidity antibodies. Forty women were given spiramycin, to prevent congenital transmission, and 7 (17.5%) had high-avidity antibodies. These findings highlight the value of testing a single serum sample obtained in the first trimester of pregnancy for IgG avidity.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
183
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1248-53
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11262207-Animals,
pubmed-meshheading:11262207-Antibodies, Protozoan,
pubmed-meshheading:11262207-Antibody Affinity,
pubmed-meshheading:11262207-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11262207-Female,
pubmed-meshheading:11262207-Hemagglutination Tests,
pubmed-meshheading:11262207-Humans,
pubmed-meshheading:11262207-Immunoglobulin E,
pubmed-meshheading:11262207-Immunoglobulin G,
pubmed-meshheading:11262207-Immunoglobulin M,
pubmed-meshheading:11262207-Pregnancy,
pubmed-meshheading:11262207-Pregnancy Complications, Parasitic,
pubmed-meshheading:11262207-Pregnancy Trimester, First,
pubmed-meshheading:11262207-Reference Values,
pubmed-meshheading:11262207-Reproducibility of Results,
pubmed-meshheading:11262207-Retrospective Studies,
pubmed-meshheading:11262207-Toxoplasma,
pubmed-meshheading:11262207-Toxoplasmosis,
pubmed-meshheading:11262207-United States
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Effect of testing for IgG avidity in the diagnosis of Toxoplasma gondii infection in pregnant women: experience in a US reference laboratory.
|
| pubmed:affiliation |
Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Ames Bldg., 795 El Camino Real, Palo Alto, CA 94301, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|