Source:http://linkedlifedata.com/resource/pubmed/id/11260482
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-3-30
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| pubmed:abstractText |
Pediatric 1-yr kidney graft survival rates have steadily improved in the US so that, by 1998, over 90% of hospital-discharged young recipients had survived the first year post-transplantation (Tx). However, 25% of the early surviving kidney grafts failed at 5 yr, yielding a projected half-life of 10 yr. Given a median age at transplant of 13 yr (range 0-20 yr), 50% of all current pediatric kidney recipients will need a second graft before the age of 25 years. We examined 8,422 pediatric renal transplants reported to the United Network for Organ Sharing (UNOS) Kidney Transplant Registry and, by using a log-linear multifactorial analysis, determined the relative influence of 26 major transplant factors on long-term graft survival. Results are reported as percentages of assignable variation (totaling 100% for all 26 factors combined) in pediatric outcomes beyond 1 yr and as adjusted graft survival rates. Transplant center, recipient race and age, transplant year, and panel-reactive antibody (PRA) had assignable variation percentages of 25, 24, 16, 12, and 4, respectively. When combined, they accounted for 81% of changes in long-term survival. Besides center effects, Blacks, teenagers, and transplants performed before 1994 exhibited significantly (p <0.0001) lower adjusted 5-yr graft survival rates as did the few sensitized (PRA>40%) pediatric patients (p = 0.02). Patients transplanted with a living donor kidney demonstrated a 5% point advantage at 5 yr post-Tx over cadaver donor kidneys (p = 0.001). Although the survival rate of pediatric kidney transplants has improved steadily, the long-term outcomes for teenagers and for Black recipients lag significantly behind those of younger patients and non-Blacks.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1397-3142
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
5-15
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11260482-Adolescent,
pubmed-meshheading:11260482-Adult,
pubmed-meshheading:11260482-Analysis of Variance,
pubmed-meshheading:11260482-Child,
pubmed-meshheading:11260482-Child, Preschool,
pubmed-meshheading:11260482-Female,
pubmed-meshheading:11260482-Graft Survival,
pubmed-meshheading:11260482-Humans,
pubmed-meshheading:11260482-Infant,
pubmed-meshheading:11260482-Infant, Newborn,
pubmed-meshheading:11260482-Kidney Transplantation,
pubmed-meshheading:11260482-Living Donors,
pubmed-meshheading:11260482-Male,
pubmed-meshheading:11260482-Middle Aged,
pubmed-meshheading:11260482-Registries,
pubmed-meshheading:11260482-Risk Factors,
pubmed-meshheading:11260482-Survival Rate,
pubmed-meshheading:11260482-Time Factors,
pubmed-meshheading:11260482-Treatment Outcome
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| pubmed:year |
2001
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| pubmed:articleTitle |
Determinants of long-term survival of pediatric kidney grafts reported to the United Network for Organ Sharing kidney transplant registry.
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| pubmed:affiliation |
The United Network for Organ Sharing (UNOS), Scientific Renal Transplant Registry and the Department of Pathology, University of California, Los Angeles, USA.
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| pubmed:publicationType |
Journal Article
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