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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
2001-3-22
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pubmed:abstractText |
The efficacy of topical glucocorticosteroids in rhinitis and asthma is likely to depend on drug retention in the airway mucosa. With fluticasone propionate, retention may be achieved exclusively by lipophilicity, whereas for budesonide an additional possibility may be provided by its ability to form fatty acid esters in the airway mucosa that release the active drug. The aim of the present study was to determine the nasal mucosal retention of budesonide and fluticasone propionate, and the occurrence of budesonide-esters (budesonide-oleate, budesonide-palmitate) in the nasal mucosa.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
|
pubmed:issn |
0306-5251
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
51
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
159-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
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pubmed:year |
2001
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pubmed:articleTitle |
Nasal retention of budesonide and fluticasone in man: formation of airway mucosal budesonide-esters in vivo.
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pubmed:affiliation |
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Reykjavik, Iceland.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
