Linked Life Data

11257264

Source:http://linkedlifedata.com/resource/pubmed/id/11257264

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-3-21
pubmed:abstractText
Human serum paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme that is responsible for the protective effect of HDL against oxidation of low-density lipoprotein (LDL). PON1 has a Glu to Arg polymorphism at codon 192 (CGA-->CAA) which is designated R/Q192. The R/Q192 polymorphism has been associated with coronary artery disease (CAD) in several, but not all, case-control studies. We prospectively studied the association of the Q/R192 genotypes with the severity, progression and regression of CAD, plasma lipid levels, clinical events and response to treatment with fluvastatin in a well-characterized cohort. Genotypes were determined by polymerase chain reaction (PCR) and restriction mapping with AlwI enzyme in 356 subjects in the Lipoprotein and Coronary Atherosclerosis Study (LCAS). Fasting plasma lipids were measured and quantitative coronary angiograms were obtained at baseline and 2.5 years following randomization to fluvastatin or placebo. A total of 177 (50%), 142 (40%) and 37 (10%) subjects had Q/Q, Q/R and R/R genotypes, respectively. Baseline and final plasma levels of HDL, LDL, triglyceride and other lipoproteins, lesion-specific minimum lumen diameters (MLD), mean MLD, number of coronary lesions and total occlusions at baseline and follow-up and clinical event rates were not significantly different among the genotypes. There was no genotype-treatment interaction with respect to plasma lipid levels and angiographic indices of CAD. The Q/R192 variants of PON1 are not associated with severity, progression or regression of coronary atherosclerosis, plasma lipid levels, clinical events, or response to treatment with fluvastatin. Thus, the Q/R192 polymorphism is not a major risk factor in susceptibility to CAD in the LCAS population.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
633-40
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11257264-Aged, pubmed-meshheading:11257264-Anticholesteremic Agents, pubmed-meshheading:11257264-Aryldialkylphosphatase, pubmed-meshheading:11257264-Cohort Studies, pubmed-meshheading:11257264-Coronary Angiography, pubmed-meshheading:11257264-Coronary Artery Disease, pubmed-meshheading:11257264-Disease Progression, pubmed-meshheading:11257264-Esterases, pubmed-meshheading:11257264-Fatty Acids, Monounsaturated, pubmed-meshheading:11257264-Female, pubmed-meshheading:11257264-Genotype, pubmed-meshheading:11257264-Humans, pubmed-meshheading:11257264-Indoles, pubmed-meshheading:11257264-Lipids, pubmed-meshheading:11257264-Male, pubmed-meshheading:11257264-Middle Aged, pubmed-meshheading:11257264-Polymorphism, Genetic, pubmed-meshheading:11257264-Prospective Studies, pubmed-meshheading:11257264-Severity of Illness Index
pubmed:year
2001
pubmed:articleTitle
A prospective study of paraoxonase gene Q/R192 polymorphism and severity, progression and regression of coronary atherosclerosis, plasma lipid levels, clinical events and response to fluvastatin.
pubmed:affiliation
Department of Medicine, Sections of Cardiology and Atherosclerosis, Baylor College of Medicine, Houston, TX 77030, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial, Research Support, Non-U.S. Gov't