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rdf:type |
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lifeskim:mentions |
umls-concept:C0007578,
umls-concept:C0017262,
umls-concept:C0019704,
umls-concept:C0021311,
umls-concept:C0023884,
umls-concept:C0033414,
umls-concept:C0033684,
umls-concept:C0086418,
umls-concept:C0205250,
umls-concept:C0225336,
umls-concept:C0439640,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0913092,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
6
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pubmed:dateCreated |
2001-3-21
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pubmed:databankReference |
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pubmed:abstractText |
The discovery of dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN) as a DC-specific ICAM-3 binding receptor that enhances HIV-1 infection of T cells in trans has indicated a potentially important role for adhesion molecules in AIDS pathogenesis. A related molecule called DC-SIGNR exhibits 77% amino acid sequence identity with DC-SIGN. The DC-SIGN and DC-SIGNR genes map within a 30-kb region on chromosome 19p13.2-3. Their strong homology and close physical location indicate a recent duplication of the original gene. Messenger RNA and protein expression patterns demonstrate that the DC-SIGN-related molecule is highly expressed on liver sinusoidal cells and in the lymph node but not on DCs, in contrast to DC-SIGN. Therefore, we suggest that a more appropriate name for the DC-SIGN-related molecule is L-SIGN, liver/lymph node-specific ICAM-3-grabbing nonintegrin. We show that in the liver, L-SIGN is expressed by sinusoidal endothelial cells. Functional studies indicate that L-SIGN behaves similarly to DC-SIGN in that it has a high affinity for ICAM-3, captures HIV-1 through gp120 binding, and enhances HIV-1 infection of T cells in trans. We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10072769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10352301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10397743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10697122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10721994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10721995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10725420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10807504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-10975799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-1371878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-1518869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-1618696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-1621951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-1736938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-2909656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-7531918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-8006603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-8030938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-8145033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-8301058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-9247650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-9525576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-9696790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11257134-9725235
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CLEC4M protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/DC-specific ICAM-3 grabbing...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/ICAM3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, HIV,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
pubmed-author:BashirovaA AAA,
pubmed-author:CarringtonMM,
pubmed-author:EileringJ BJB,
pubmed-author:GeijtenbeekT BTB,
pubmed-author:KewalRamaniV NVN,
pubmed-author:KnolleP APA,
pubmed-author:MartinM PMP,
pubmed-author:MartinT DTD,
pubmed-author:ViebigNN,
pubmed-author:WuLL,
pubmed-author:van DuijnhovenG CGC,
pubmed-author:van KooykYY,
pubmed-author:van VlietS JSJ
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
193
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
671-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11257134-Humans,
pubmed-meshheading:11257134-Animals,
pubmed-meshheading:11257134-Mice,
pubmed-meshheading:11257134-Liver,
pubmed-meshheading:11257134-Endothelium,
pubmed-meshheading:11257134-Base Sequence,
pubmed-meshheading:11257134-Cells, Cultured,
pubmed-meshheading:11257134-Lectins,
pubmed-meshheading:11257134-Chromosome Mapping,
pubmed-meshheading:11257134-Polymorphism, Genetic,
pubmed-meshheading:11257134-Cell Line
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