Source:http://linkedlifedata.com/resource/pubmed/id/11256883
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2001-3-20
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pubmed:abstractText |
CD95 (Fas/Apo-1) is a broadly expressed death receptor involved in a variety of physiological and pathological apoptotic processes. Since its discovery, defects in CD95/CD95L system have been proposed as major pathogenic factors responsible for impaired immunological tolerance to self antigens and autoimmunity. Later, analysis of altered sensitivity to CD95-induced apoptosis in cells targeted by the immune response has revealed an unexpected role for CD95 and CD95L in organ-specific autoimmunity. CD95 has been shown to be expressed and functional in virtually all cell types that are target of the organ-specific autoimmune response. Here we review some of the major findings concerning the role of CD95 in autoimmunity, in dysfunctions due to increased or decreased CD95-induced apoptosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1360-8185
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
419-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11256883-Animals,
pubmed-meshheading:11256883-Antigens, CD95,
pubmed-meshheading:11256883-Apoptosis,
pubmed-meshheading:11256883-Autoimmune Diseases,
pubmed-meshheading:11256883-Autoimmunity,
pubmed-meshheading:11256883-Fas Ligand Protein,
pubmed-meshheading:11256883-Humans,
pubmed-meshheading:11256883-Membrane Glycoproteins
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pubmed:year |
2000
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pubmed:articleTitle |
CD95/CD95L interactions and their role in autoimmunity.
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pubmed:affiliation |
Laboratory of Hematology and Oncology, Istituto Superiore di Sanità, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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