Linked Life Data

11256428

Source:http://linkedlifedata.com/resource/pubmed/id/11256428

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-3-20
pubmed:abstractText
The study of transplantation tolerance has been a major area of immunological research since the pioneering work by Medawar and colleagues. It has been classically defined as the absence of an immune response to a specific antigen in the setting of an otherwise normal immune system. The induction of tolerance to alloantigen in the transplantation setting would not only allow better graft survival but would also obviate the need for immunosuppressive therapy. The induction of tolerance is considered by many to be the "holy grail" of organ transplantation but, despite many years of experimental investigation, reliable induction of allograft tolerance has not been achieved in humans. There exists four fundamental mechanisms of T cell tolerance that may be operational in the transplantation setting: deletion, functional anergy, ignorance and regulation/suppression. Several strategies to induce tolerance in transplantation have been employed, but most of these tolerogenic strategies have been investigated in rodents and it remains to be determined whether they can be transferred into large outbred animal models or clinical transplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1398-1714
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
374-86
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Induction of tolerance to alloantigen.
pubmed:affiliation
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't