Source:http://linkedlifedata.com/resource/pubmed/id/11254940
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-3-20
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| pubmed:abstractText |
A large clinical literature suggests that estradiol (E(2)) plays a critical role in immune function. To further explore the relationship between E(2) and immune function, we examined a variety of immunological parameters in a rhesus monkey model of menopause and hormone replacement therapy. Rhesus monkeys (Age, 13.7+/-2.6 years) were ovariectomized and received either sham (n=10) or estradiol (n=10) replacement implants. Nine months post-ovariectomy, a variety of immunologic parameters were measured. E(2)-deprivation reduced natural killer cell activity and increased serum soluble gp130 levels. There was a trend for an increased proportion of CD8(+) (P=0.12) and HLA-DR(+)CD3(+) cells (P=0.15) and decreased proportion of eosinophils (P=0.11) in the E(2)-deprived monkeys. There was no difference in leukocyte distribution, CD28, CD56, CD4, CD8/CD45, colony forming units-granulocyte/monocytes formation, peripheral blood mononuclear cell apoptotic rate, or serum TNF, TNF-R1, TNF-R2, IL-6, soluble IL-6R, and IL-1 between the groups. These data demonstrate that E(2)-deprivation affects several aspects of immune function. These findings may have implications for menopause-associated changes of immune function that occur in women.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
0165-0378
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
50
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
41-55
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11254940-Animals,
pubmed-meshheading:11254940-Apoptosis,
pubmed-meshheading:11254940-Colony-Forming Units Assay,
pubmed-meshheading:11254940-Cytokines,
pubmed-meshheading:11254940-Cytotoxicity, Immunologic,
pubmed-meshheading:11254940-Drug Implants,
pubmed-meshheading:11254940-Estradiol,
pubmed-meshheading:11254940-Estrogens,
pubmed-meshheading:11254940-Female,
pubmed-meshheading:11254940-Granulocytes,
pubmed-meshheading:11254940-Humans,
pubmed-meshheading:11254940-Jurkat Cells,
pubmed-meshheading:11254940-Killer Cells, Natural,
pubmed-meshheading:11254940-Leukocyte Count,
pubmed-meshheading:11254940-Lymphocyte Subsets,
pubmed-meshheading:11254940-Macaca mulatta,
pubmed-meshheading:11254940-Menopause,
pubmed-meshheading:11254940-Models, Immunological,
pubmed-meshheading:11254940-Monocytes,
pubmed-meshheading:11254940-Ovariectomy
|
| pubmed:year |
2001
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| pubmed:articleTitle |
The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause.
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| pubmed:affiliation |
Unit for Laboratory Animal Medicine, Rm 5304 CCGCB, 1500 E. Medical Center Drive, University of Michigan, Ann Arbor, MI 48109-0940, USA. etkeller@umich.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|