Source:http://linkedlifedata.com/resource/pubmed/id/11254912
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-3-20
|
| pubmed:abstractText |
Betacellulin (BTC), a new member of the EGF family, has been reported to be a potent mitogen for rat vascular smooth muscle cells (SMCs). BTC mRNA is known to be expressed in several human organs. However, the localization of BTC in human vascular tissues has not yet been clarified. We investigated whether or not BTC protein is involved in the pathogenesis of human atherosclerosis. Recombinant human BTC showed a mitogenic activity on cultured human aortic SMCs by measuring [3H]thymidine incorporation. The immunohistochemical localization of BTC, SMCs, macrophages, EGF receptors and ErbB4 was examined in autopsied human aortas. BTC was detected in both intimal and medial SMCs of the aortic wall. The percentage of BTC-positive medial SMCs in early types of atherosclerotic lesions decreased with age, but in adult, it was significantly higher in advanced types than in early types of atherosclerotic lesions. BTC-positive SMCs were predominantly localized in the medial side of the intima. Furthermore, numerous BTC-positive SMCs and macrophages were observed around the core lesion of atherosclerotic plaques. Receptors for BTC, EGF receptor and ErbB4, were expressed on SMCs, suggesting that BTC is associated with EGF receptor family-mediated signaling. BTC is produced in human aortic tissue and might play important roles in atherogenesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/betacellulin,
http://linkedlifedata.com/resource/pubmed/chemical/receptor tyrosine-protein kinase...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0021-9150
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
155
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
413-23
|
| pubmed:dateRevised |
2011-11-2
|
| pubmed:meshHeading |
pubmed-meshheading:11254912-Adolescent,
pubmed-meshheading:11254912-Adult,
pubmed-meshheading:11254912-Aged,
pubmed-meshheading:11254912-Aging,
pubmed-meshheading:11254912-Aorta, Thoracic,
pubmed-meshheading:11254912-Aortic Diseases,
pubmed-meshheading:11254912-Arteriosclerosis,
pubmed-meshheading:11254912-Cell Division,
pubmed-meshheading:11254912-Cells, Cultured,
pubmed-meshheading:11254912-Child,
pubmed-meshheading:11254912-Child, Preschool,
pubmed-meshheading:11254912-Female,
pubmed-meshheading:11254912-Growth Substances,
pubmed-meshheading:11254912-Humans,
pubmed-meshheading:11254912-Immunoenzyme Techniques,
pubmed-meshheading:11254912-Infant,
pubmed-meshheading:11254912-Infant, Newborn,
pubmed-meshheading:11254912-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11254912-Macrophages,
pubmed-meshheading:11254912-Male,
pubmed-meshheading:11254912-Middle Aged,
pubmed-meshheading:11254912-Muscle, Smooth, Vascular,
pubmed-meshheading:11254912-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11254912-Recombinant Fusion Proteins,
pubmed-meshheading:11254912-Tunica Intima,
pubmed-meshheading:11254912-Tunica Media
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Immunohistochemical localization of Betacellulin, a member of epidermal growth factor family, in atherosclerotic plaques of human aorta.
|
| pubmed:affiliation |
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2, Yamada-oka, Suita, 565-0871, Osaka, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|