Linked Life Data

11254143

Source:http://linkedlifedata.com/resource/pubmed/id/11254143

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-3-19
pubmed:abstractText
We develop the hypothesis that parasites do not invade extreme environments, i.e. hostile hosts, but rather 'create' them. We argue that parasites may have driven the evolution of the constitutive and adaptive immune system. This leads to several implications. First, parasites respond to 'genes to kill' by 'genes to survive' and this triggers an indefinite selection of measures and counter-measures. Second, these coevolutionary arms races may lead to local adaptation, in which parasite populations perform better on local hosts. Third, the evolution of the immune system, whose responses are predictable, may allow parasites to specialize, to evade and even to manipulate. Finally we show that the correlations between the increase in the antibody repertoire, the expansion of MHC loci and parasite pressures support our hypothesis that both host complexity and parasite pressures can be invoked to explain the diversity of antibodies, T-receptors and MHC molecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0031-1820
pubmed:author
pubmed:issnType
Print
pubmed:volume
119 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S107-10
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Do parasites live in extreme environments? Constructing hostile niches and living in them.
pubmed:affiliation
Laboratoire de Biologie Animale, UMR 5555 CNRS, Centre de Biologie et d'Ecologie Tropicale et Méditerranéenne, Université de Perpignan, France. combes@univ-perp.fr
pubmed:publicationType
Journal Article, Review