Source:http://linkedlifedata.com/resource/pubmed/id/11253152
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-3-16
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pubmed:abstractText |
Little is known regarding the effects of prolonged calorie restriction (CR) on skeletal health. We investigated long-term (11 years) and short-term (12 months) effects of moderate CR on bone mass and biochemical indices of bone metabolism in male rhesus monkeys across a range of ages. A lower bone mass in long-term CR monkeys was accounted for by adjusting for age and body weight differences. A further analysis indicated that lean mass, but not fat mass, was a strong predictor of bone mass in both CR and control monkeys. No effect of short-term CR on bone mass was observed in older monkeys (mean age, 19 years), although young monkeys (4 years) subjected to short-term CR exhibited slower gains in total body bone density and content than age-matched controls. Neither biochemical markers of bone turnover nor hormonal regulators of bone metabolism were affected by long-term CR. Although osteocalcin concentrations were significantly lower in young restricted males after 1 month on 30% CR in the short-term study, they were no longer different from control values by 6 months on 30% CR.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1079-5006
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
B98-107
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11253152-Animals,
pubmed-meshheading:11253152-Body Composition,
pubmed-meshheading:11253152-Body Constitution,
pubmed-meshheading:11253152-Bone Density,
pubmed-meshheading:11253152-Bone and Bones,
pubmed-meshheading:11253152-Energy Intake,
pubmed-meshheading:11253152-Macaca mulatta,
pubmed-meshheading:11253152-Male,
pubmed-meshheading:11253152-Organ Size,
pubmed-meshheading:11253152-Osmolar Concentration,
pubmed-meshheading:11253152-Osteocalcin,
pubmed-meshheading:11253152-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Calorie restriction and skeletal mass in rhesus monkeys (Macaca mulatta): evidence for an effect mediated through changes in body size.
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pubmed:affiliation |
Molecular and Nutritional Physiology Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA.
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pubmed:publicationType |
Journal Article,
In Vitro
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