Linked Life Data

1125264

Source:http://linkedlifedata.com/resource/pubmed/id/1125264

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1975-7-23
pubmed:abstractText
Synthetic substance P stimulated adenylate cyclase activity in particulate preparations from rat and human brain. The concentration of substance P for half maximal stimulation in rat brain was 1.8-10-minus 7 M. The stimulatory effect of substance P on the rat brain adenylate cyclase activity was 88% compared with 48% by noradrenalin, 163% by prostaglandin E1 and 184% by prostaglandin E2. Both the basal and substance P-stimulated adenylate cyclase activity in rat brain were inhibited by concentration of Ca-2+ above 10-minus 6 M. The chelating agent ethyleneglycol-bis-(beta-aminoethylether)-N, N'-tetraacetic acid at a concentration of 0.1 mM reduced the basal adenylate cyclase activity by 64% and eliminated the substance P-stimulated activity. The inhibition by ethyleneglycol-bis-(beta-aminoethylether)-N, N'-tetraacetic acid was completely reversed by increasing concentrations of Ca-2+.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
385
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-80
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Stimulation of brain adenylate cyclase activity by the undecapeptide substance P and its modulation by the calcium ion.
pubmed:publicationType
Journal Article