| pubmed-article:11251968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C1514475 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C0599896 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C1441414 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C0887808 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C1880945 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C1578820 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C1553874 | lld:lifeskim |
| pubmed-article:11251968 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11251968 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11251968 | pubmed:dateCreated | 2001-3-19 | lld:pubmed |
| pubmed-article:11251968 | pubmed:abstractText | Human cancer is characterized by complex molecular perturbations leading to variable clinical behavior, often even in single-disease entities. We performed a feasibility study systematically comparing large-scale gene expression profiles with clinical features in human B-cell chronic lymphocytic leukemia (B-CLL). cDNA microarrays were employed to determine the expression levels of 1,024 selected genes in 54 peripheral blood lymphocyte samples obtained from patients with B-CLL. Statistical analyses were applied to correlate the expression profiles with a number of clinical parameters including patient survival and disease staging. We were able to identify genes whose expression levels significantly correlated with patient survival and/or with clinical staging. Most of these genes code either for cell adhesion molecules (L-selectin, integrin-beta2) or for factors inducing cell adhesion molecules (IL-1beta, IL-8, EGR1), suggesting that prognosis of this disease may be related to a defect in lymphocyte trafficking. This report demonstrates the feasibility of a systematic integration of large-scale gene expression profiles with clinical data as a general approach for dissecting human diseases. | lld:pubmed |
| pubmed-article:11251968 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11251968 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11251968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11251968 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11251968 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:11251968 | pubmed:author | pubmed-author:LöfflerGG | lld:pubmed |
| pubmed-article:11251968 | pubmed:author | pubmed-author:DöhnerHH | lld:pubmed |
| pubmed-article:11251968 | pubmed:author | pubmed-author:LichterPP | lld:pubmed |
| pubmed-article:11251968 | pubmed:author | pubmed-author:WilgenbusK... | lld:pubmed |
| pubmed-article:11251968 | pubmed:author | pubmed-author:SchweiferNN | lld:pubmed |
| pubmed-article:11251968 | pubmed:author | pubmed-author:StilgenbauerS... | lld:pubmed |
| pubmed-article:11251968 | pubmed:author | pubmed-author:StratowaCC | lld:pubmed |
| pubmed-article:11251968 | pubmed:author | pubmed-author:HaberlPP | lld:pubmed |
| pubmed-article:11251968 | pubmed:copyrightInfo | Copyright 2001 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:11251968 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11251968 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11251968 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:11251968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11251968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11251968 | pubmed:pagination | 474-80 | lld:pubmed |
| pubmed-article:11251968 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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| pubmed-article:11251968 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11251968 | pubmed:articleTitle | CDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking. | lld:pubmed |
| pubmed-article:11251968 | pubmed:affiliation | Boehringer Ingelheim Austria, Exploratory Research, Dr. Boehringergasse 5-11, A-1121 Vienna, Austria. christian.stratowa@vie.boehringer-ingelheim.com | lld:pubmed |
| pubmed-article:11251968 | pubmed:publicationType | Journal Article | lld:pubmed |
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