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rdf:type |
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lifeskim:mentions |
umls-concept:C0023434,
umls-concept:C0024264,
umls-concept:C0035647,
umls-concept:C0599896,
umls-concept:C0887808,
umls-concept:C1314939,
umls-concept:C1441414,
umls-concept:C1514475,
umls-concept:C1553874,
umls-concept:C1578820,
umls-concept:C1880945
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pubmed:issue |
4
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pubmed:dateCreated |
2001-3-19
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pubmed:abstractText |
Human cancer is characterized by complex molecular perturbations leading to variable clinical behavior, often even in single-disease entities. We performed a feasibility study systematically comparing large-scale gene expression profiles with clinical features in human B-cell chronic lymphocytic leukemia (B-CLL). cDNA microarrays were employed to determine the expression levels of 1,024 selected genes in 54 peripheral blood lymphocyte samples obtained from patients with B-CLL. Statistical analyses were applied to correlate the expression profiles with a number of clinical parameters including patient survival and disease staging. We were able to identify genes whose expression levels significantly correlated with patient survival and/or with clinical staging. Most of these genes code either for cell adhesion molecules (L-selectin, integrin-beta2) or for factors inducing cell adhesion molecules (IL-1beta, IL-8, EGR1), suggesting that prognosis of this disease may be related to a defect in lymphocyte trafficking. This report demonstrates the feasibility of a systematic integration of large-scale gene expression profiles with clinical data as a general approach for dissecting human diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD18,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EGR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/L-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
474-80
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:11251968-Adult,
pubmed-meshheading:11251968-Aged,
pubmed-meshheading:11251968-Aged, 80 and over,
pubmed-meshheading:11251968-Antigens, CD18,
pubmed-meshheading:11251968-Cell Adhesion,
pubmed-meshheading:11251968-DNA, Complementary,
pubmed-meshheading:11251968-DNA-Binding Proteins,
pubmed-meshheading:11251968-Early Growth Response Protein 1,
pubmed-meshheading:11251968-Feasibility Studies,
pubmed-meshheading:11251968-Female,
pubmed-meshheading:11251968-Flow Cytometry,
pubmed-meshheading:11251968-Humans,
pubmed-meshheading:11251968-Immediate-Early Proteins,
pubmed-meshheading:11251968-Immunohistochemistry,
pubmed-meshheading:11251968-Immunophenotyping,
pubmed-meshheading:11251968-Interleukin-1,
pubmed-meshheading:11251968-Interleukin-8,
pubmed-meshheading:11251968-L-Selectin,
pubmed-meshheading:11251968-Leukemia, B-Cell,
pubmed-meshheading:11251968-Lymphocytes,
pubmed-meshheading:11251968-Male,
pubmed-meshheading:11251968-Middle Aged,
pubmed-meshheading:11251968-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:11251968-Plasmids,
pubmed-meshheading:11251968-Prognosis,
pubmed-meshheading:11251968-RNA,
pubmed-meshheading:11251968-Time Factors,
pubmed-meshheading:11251968-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
CDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking.
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pubmed:affiliation |
Boehringer Ingelheim Austria, Exploratory Research, Dr. Boehringergasse 5-11, A-1121 Vienna, Austria. christian.stratowa@vie.boehringer-ingelheim.com
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pubmed:publicationType |
Journal Article
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