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rdf:type |
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lifeskim:mentions |
umls-concept:C0016011,
umls-concept:C0030705,
umls-concept:C0036043,
umls-concept:C0162577,
umls-concept:C0205360,
umls-concept:C0231491,
umls-concept:C0439608,
umls-concept:C0442027,
umls-concept:C0597357,
umls-concept:C0665278,
umls-concept:C0851347,
umls-concept:C1416485,
umls-concept:C1956346
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pubmed:issue |
4
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pubmed:dateCreated |
2001-3-19
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pubmed:abstractText |
Lefradafiban is the orally active prodrug of fradafiban, a glycoprotein IIb/IIIa receptor antagonist. The present phase II study aimed to determine the dose of lefradafiban that provides 80% blockade of the glycoprotein IIb/IIIa receptors by fradafiban, and to study the pharmacodynamics and safety of different doses in patients with stable angina undergoing angioplasty.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-10341274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-10482148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-10577636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-1727977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-2239976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-3109764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-3121710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-3604939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-7739710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-7930190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-9286940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-9443422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-9468207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-9540764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-9751674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-9787160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11250974-9950658
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1468-201X
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pubmed:author |
pubmed-author:AkkerhuisK MKM,
pubmed-author:BaardmanTT,
pubmed-author:DeckersJ WJW,
pubmed-author:HoffmannJJ,
pubmed-author:PeelsH OHO,
pubmed-author:SimoonsM LML,
pubmed-author:StibbeJJ,
pubmed-author:SuryapranataHH,
pubmed-author:van Den BrandM JMJ,
pubmed-author:van Der WiekenL RLR,
pubmed-author:van Der ZwaanCC
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pubmed:issnType |
Electronic
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
444-50
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11250974-Administration, Oral,
pubmed-meshheading:11250974-Aged,
pubmed-meshheading:11250974-Angioplasty, Balloon, Coronary,
pubmed-meshheading:11250974-Area Under Curve,
pubmed-meshheading:11250974-Biphenyl Compounds,
pubmed-meshheading:11250974-Coronary Disease,
pubmed-meshheading:11250974-Double-Blind Method,
pubmed-meshheading:11250974-Female,
pubmed-meshheading:11250974-Hemorrhage,
pubmed-meshheading:11250974-Hemostasis,
pubmed-meshheading:11250974-Humans,
pubmed-meshheading:11250974-Logistic Models,
pubmed-meshheading:11250974-Male,
pubmed-meshheading:11250974-Middle Aged,
pubmed-meshheading:11250974-Platelet Aggregation,
pubmed-meshheading:11250974-Platelet Aggregation Inhibitors,
pubmed-meshheading:11250974-Platelet Glycoprotein GPIIb-IIIa Complex,
pubmed-meshheading:11250974-Prodrugs,
pubmed-meshheading:11250974-Pyrrolidines,
pubmed-meshheading:11250974-Risk
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pubmed:year |
2001
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pubmed:articleTitle |
Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty.
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pubmed:affiliation |
Thoraxcenter, Erasmus University and University Hospital Rotterdam, Netherlands. makkerhuis@cardialysis.nl
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase II
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