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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-7-11
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pubmed:abstractText |
Interferon-gamma (IFN-gamma) is a homodimeric cytokine that exerts its various activities by inducing the aggregation of two different receptors. The alpha chain receptor (IFN-gammaRalpha) is a high affinity receptor that binds to IFN-gamma in a symmetric bivalent manner to form a stable, intermediate 1:2 complex. This intermediate forms a binding template for the subsequent binding of two copies of the second receptor, beta chain receptor (IFN-gammaRbeta), producing the active 1:2:2 signaling complex.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-63
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11250200-Antiviral Agents,
pubmed-meshheading:11250200-Crystallography, X-Ray,
pubmed-meshheading:11250200-Hydrogen Bonding,
pubmed-meshheading:11250200-Interferon-gamma,
pubmed-meshheading:11250200-Models, Molecular,
pubmed-meshheading:11250200-Molecular Structure,
pubmed-meshheading:11250200-Protein Structure, Quaternary,
pubmed-meshheading:11250200-Protein Structure, Tertiary,
pubmed-meshheading:11250200-Receptors, Interferon,
pubmed-meshheading:11250200-Signal Transduction,
pubmed-meshheading:11250200-Solvents
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pubmed:year |
2001
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pubmed:articleTitle |
The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
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pubmed:affiliation |
Graduate Group in Biophysics, University of California, 94000, San Francisco, CA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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