Source:http://linkedlifedata.com/resource/pubmed/id/11250125
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-3-16
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pubmed:abstractText |
Growing evidence suggests that interleukin-6 (IL-6) may play a pathogenetic role in postmenopausal bone loss and in other age-related pathological conditions. In this study, we have examined the age-related changes in the serum levels of IL-6 and the soluble receptors that modulate its biological activity--soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130)--in 220 women (from 25 to 104yr old), including 22 centenarians. Serum IL-6 rose exponentially with age (r=0.74, p<0.0001). The median level of IL-6 increased almost ten-fold with age, from 1.16pg/ml in premenopausal women to 10.27pg/ml in centenarians. Serum sIL-6R and sgp130 showed an increase until the seventh decade and a progressive decrease in older ages (r=0.39, p<0.0001 and r=0.26, p=0.008, respectively). IL-6, sIL-6R and sgp130 were significantly higher in women within 10yr of menopause as compared to premenopausal subjects (1.51 vs. 1.16pg/ml, p=0.012; 41.9 vs. 35.7ng/ml, p=0.002; and 253.4 vs. 230.7ng/ml, p=0.008, respectively). In postmenopausal women, a negative correlation was found between sIL-6R and the lumbar bone mineral density (BMD) (r=-0.28, p=0.002) even after adjusting for age and weight. Furthermore, sIL-6R levels were higher in osteoporotic compared to normal women (47.9 vs. 39.5ng/ml, p=0.001). In conclusion, our results show that the serum levels of IL-6, sIL-6R and sgp130 exhibit different patterns of age- and menopause-related changes, and that the biological activity of IL-6 may be increased with age with potential implications in the age-related diseases such as osteoporosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Neural Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/cell adhesion molecule F11
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0531-5565
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
547-57
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11250125-Adult,
pubmed-meshheading:11250125-Aged,
pubmed-meshheading:11250125-Aged, 80 and over,
pubmed-meshheading:11250125-Aging,
pubmed-meshheading:11250125-Female,
pubmed-meshheading:11250125-Humans,
pubmed-meshheading:11250125-Interleukin-6,
pubmed-meshheading:11250125-Menopause,
pubmed-meshheading:11250125-Middle Aged,
pubmed-meshheading:11250125-Neural Cell Adhesion Molecules,
pubmed-meshheading:11250125-Postmenopause,
pubmed-meshheading:11250125-Premenopause,
pubmed-meshheading:11250125-Receptors, Interleukin-6,
pubmed-meshheading:11250125-Regression Analysis
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pubmed:year |
2001
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pubmed:articleTitle |
Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes.
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pubmed:affiliation |
Dipartimento di Medicina Interna e Scienze Biomediche, Università di Parma, via Gramsci 14, 43100, Parma, Italy.
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pubmed:publicationType |
Journal Article
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