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pubmed-article:11249126pubmed:abstractTextFourteen novel C-prenylated and O-allylated 1,3-diarylpropenones (chalcones) were synthesized by Claisen-Schmidt condensation reaction of C-prenylated/O-allylated acetophenones with appropriate aldehydes; twelve of these model chalcones were screened in an assay based on the confrontation of invasive human MCF-7/6 mammary carcinoma cells with fragments of normal embryonic chick heart in vitro. Out of the twelve chalcones tested, three were found to exhibit potent anti-invasive activity. Some of these chalcones and their precursor acetophenones were also tested for inhibition of initiation of lipid peroxidation in rat liver microsomes; a prenylated acetophenone carrying two methoxy groups and two free phenolic hydroxy functions was found to be a potential antioxidant.lld:pubmed
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pubmed-article:11249126pubmed:articleTitleSynthetic and biological activity evaluation studies on novel 1,3-diarylpropenones.lld:pubmed
pubmed-article:11249126pubmed:affiliationDepartment of Chemistry, University of Delhi, India.lld:pubmed
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