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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-3-15
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pubmed:abstractText |
Fourteen novel C-prenylated and O-allylated 1,3-diarylpropenones (chalcones) were synthesized by Claisen-Schmidt condensation reaction of C-prenylated/O-allylated acetophenones with appropriate aldehydes; twelve of these model chalcones were screened in an assay based on the confrontation of invasive human MCF-7/6 mammary carcinoma cells with fragments of normal embryonic chick heart in vitro. Out of the twelve chalcones tested, three were found to exhibit potent anti-invasive activity. Some of these chalcones and their precursor acetophenones were also tested for inhibition of initiation of lipid peroxidation in rat liver microsomes; a prenylated acetophenone carrying two methoxy groups and two free phenolic hydroxy functions was found to be a potential antioxidant.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-45
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11249126-Acetophenones,
pubmed-meshheading:11249126-Animals,
pubmed-meshheading:11249126-Antineoplastic Agents,
pubmed-meshheading:11249126-Antioxidants,
pubmed-meshheading:11249126-Breast Neoplasms,
pubmed-meshheading:11249126-Chalcone,
pubmed-meshheading:11249126-Chick Embryo,
pubmed-meshheading:11249126-Coculture Techniques,
pubmed-meshheading:11249126-Combinatorial Chemistry Techniques,
pubmed-meshheading:11249126-Drug Evaluation, Preclinical,
pubmed-meshheading:11249126-Female,
pubmed-meshheading:11249126-Humans,
pubmed-meshheading:11249126-Lipid Peroxidation,
pubmed-meshheading:11249126-Microsomes, Liver,
pubmed-meshheading:11249126-Myocardium,
pubmed-meshheading:11249126-Neoplasm Invasiveness,
pubmed-meshheading:11249126-Rats,
pubmed-meshheading:11249126-Structure-Activity Relationship,
pubmed-meshheading:11249126-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones.
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pubmed:affiliation |
Department of Chemistry, University of Delhi, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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