Linked Life Data

11247125

Source:http://linkedlifedata.com/resource/pubmed/id/11247125

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-3-14
pubmed:abstractText
Glucocorticosteroids (GC) are the true immunomodulators that can depress and enhance immune reactions. Hormone-activated GC receptors (GCR) change the transcription of many genes, resulting in modified immune responses. The direction of immunomodulation under which GC act depends on their level, the quantity and state of GCR, the amount of different cytokines and cytokine receptors and other immunoactive molecules. The modulation of proinflammatory (IL-1 beta, IL-6, TNF-alpha) cytokine production by human peripheral lymphocytes treated with a wide range of dexamethasone (10(-6)-10(-12) mol) in the serum-free culture medium was observed in the present study. Enhanced or suppressed cytokine release depends on GC doses, intermittent or continuous contact with the hormone and cell environment. The magnitude of changes in IL-1 beta and TNF-alpha production was similar (parallel stimulation or depression) while diminished TNF-alpha was observed simultaneously with enhanced IL-6 production and vice versa. The suppression of proinflammatory cytokine production by GC is well documented. The experimental conditions of increased cytokine release with dexamethasone in the serum-free culture medium can serve as a model of investigation in false results of steroid immunosuppression.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0869-6047
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-45
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
[Increased proinflammatory cytokine production by human peripheral lymphocytes treated with glucocorticoids].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract