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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-3-14
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pubmed:abstractText |
Adenosine decreases the cerebral metabolic rate for oxygen and increases cerebral blood flow, and it may play an important role in cerebrometabolic and cerebrovascular responses to hypoperfusion after traumatic brain injury. Jugular venous oxygen saturation is monitored after traumatic brain injury to assess brain oxygen extraction, and desaturations may reflect secondary brain insults. We hypothesized that brain interstitial adenosine and related purine metabolites would be increased during jugular venous oxygen saturation desaturations (<50%) and determined associations between the purines, lactate, and glucose to assess the role of adenosine during secondary insults in humans.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0090-3493
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
399-404
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11246323-Adenosine,
pubmed-meshheading:11246323-Adolescent,
pubmed-meshheading:11246323-Adult,
pubmed-meshheading:11246323-Blood Gas Analysis,
pubmed-meshheading:11246323-Blood Glucose,
pubmed-meshheading:11246323-Brain Chemistry,
pubmed-meshheading:11246323-Brain Injuries,
pubmed-meshheading:11246323-Cerebrovascular Circulation,
pubmed-meshheading:11246323-Chromatography, High Pressure Liquid,
pubmed-meshheading:11246323-Critical Illness,
pubmed-meshheading:11246323-Cyclic AMP,
pubmed-meshheading:11246323-Extracellular Space,
pubmed-meshheading:11246323-Glycolysis,
pubmed-meshheading:11246323-Humans,
pubmed-meshheading:11246323-Hypoxia, Brain,
pubmed-meshheading:11246323-Jugular Veins,
pubmed-meshheading:11246323-Lactic Acid,
pubmed-meshheading:11246323-Male,
pubmed-meshheading:11246323-Microdialysis,
pubmed-meshheading:11246323-Middle Aged,
pubmed-meshheading:11246323-Oxygen Consumption,
pubmed-meshheading:11246323-Prospective Studies,
pubmed-meshheading:11246323-Xanthine
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pubmed:year |
2001
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pubmed:articleTitle |
Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury.
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pubmed:affiliation |
Safar Center for Resuscitation Research and the University of Pittsburgh Brain Trauma Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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