|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021083,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0027651,
umls-concept:C0039194,
umls-concept:C0441712,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C0947647,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:dateCreated |
2001-3-13
|
|
pubmed:abstractText |
The T cell compartment of adaptive immunity provides vertebrates with the potential to survey for and respond specifically to an incredible diversity of antigens. The T cell repertoire must be carefully regulated to prevent unwanted responses to self. In the periphery, one important level of regulation is the action of costimulatory signals in concert with T cell antigen-receptor (TCR) signals to promote full T cell activation. The past few years have revealed that costimulation is quite complex, involving an integration of activating signals and inhibitory signals from CD28 and CTLA-4 molecules, respectively, with TCR signals to determine the outcome of a T cell's encounter with antigen. Newly emerging data suggest that inhibitory signals mediated by CTLA-4 not only can determine whether T cells become activated, but also can play a role in regulating the clonal representation in a polyclonal response. This review primarily focuses on the cellular and molecular mechanisms of regulation by CTLA-4 and its manipulation as a strategy for tumor immunotherapy.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0732-0582
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
565-94
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:11244047-Adenocarcinoma,
pubmed-meshheading:11244047-Amino Acid Motifs,
pubmed-meshheading:11244047-Animals,
pubmed-meshheading:11244047-Antibodies, Monoclonal,
pubmed-meshheading:11244047-Antigens, CD,
pubmed-meshheading:11244047-Antigens, CD28,
pubmed-meshheading:11244047-Antigens, Differentiation,
pubmed-meshheading:11244047-CTLA-4 Antigen,
pubmed-meshheading:11244047-Cell Cycle,
pubmed-meshheading:11244047-Cell Differentiation,
pubmed-meshheading:11244047-Clonal Anergy,
pubmed-meshheading:11244047-Cytokines,
pubmed-meshheading:11244047-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:11244047-Female,
pubmed-meshheading:11244047-Humans,
pubmed-meshheading:11244047-Immune Tolerance,
pubmed-meshheading:11244047-Immunoconjugates,
pubmed-meshheading:11244047-Immunotherapy,
pubmed-meshheading:11244047-Lymphocyte Activation,
pubmed-meshheading:11244047-Lymphoproliferative Disorders,
pubmed-meshheading:11244047-Macromolecular Substances,
pubmed-meshheading:11244047-Male,
pubmed-meshheading:11244047-Mammary Neoplasms, Experimental,
pubmed-meshheading:11244047-Melanoma, Experimental,
pubmed-meshheading:11244047-Mice,
pubmed-meshheading:11244047-Mice, Knockout,
pubmed-meshheading:11244047-Models, Immunological,
pubmed-meshheading:11244047-Neoplasms,
pubmed-meshheading:11244047-Prostatic Neoplasms,
pubmed-meshheading:11244047-Receptors, Antigen, T-Cell,
pubmed-meshheading:11244047-T-Lymphocyte Subsets,
pubmed-meshheading:11244047-T-Lymphocytes, Helper-Inducer
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy.
|
|
pubmed:affiliation |
University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
|
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|
