Source:http://linkedlifedata.com/resource/pubmed/id/11242187
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
Human herpesvirus 8 (HHV-8) is closely associated with Kaposi's sarcoma (KS), HIV-associated Castleman's disease, and primary effusion lymphoma. As a high frequency of non-Hodgkin's lymphoma (NHL) has been reported in patients with HIV-associated KS, we hypothesized that HHV-8 infection could be indirectly implicated in the pathogenesis of NHL. We assessed the prevalence of HHV-8 antibodies in 63 patients with NHL compared with 126 HIV-infected matched control patients without NHL. Serum samples from cases and controls were assayed for antibodies to HHV-8 lytic and latent antigens using an indirect immunofluorescence assay. In patients with concordant serologic results, HHV-8 antibodies were detected in 41.5% of the NHL cases and 37% of the controls. This absence of a significant difference in HHV-8 seroprevalence between cases and controls (p =.73) does not support a possible role for HHV-8 infection in the development of NHL in HIV-infected patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1525-4135
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
182-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11242187-Adolescent,
pubmed-meshheading:11242187-Adult,
pubmed-meshheading:11242187-Antibodies, Viral,
pubmed-meshheading:11242187-Female,
pubmed-meshheading:11242187-HIV Infections,
pubmed-meshheading:11242187-Herpesvirus 8, Human,
pubmed-meshheading:11242187-Humans,
pubmed-meshheading:11242187-Lymphoma, Non-Hodgkin,
pubmed-meshheading:11242187-Male,
pubmed-meshheading:11242187-Middle Aged,
pubmed-meshheading:11242187-Seroepidemiologic Studies
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pubmed:year |
2001
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pubmed:articleTitle |
No increased human herpesvirus 8 seroprevalence in patients with HIV-associated non-Hodgkin's lymphoma.
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pubmed:affiliation |
Department of Immunology and Hematology, Hôpital Saint-Louis, Paris, France. laurence. gerard@sls.ap-hop-paris.fr
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pubmed:publicationType |
Journal Article,
Comparative Study
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