Source:http://linkedlifedata.com/resource/pubmed/id/11241320
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-3-12
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| pubmed:abstractText |
Desmoids represent the most important cause of death, after colorectal cancer, in patients affected with familial adenomatous polyposis (FAP), an inherited disease due to mutations in the APC gene. The aims of our study were to estimate the risk of developing desmoids in FAP patients and to evaluate the association between desmoids and different risk factors. The occurrence of desmoids, colorectal cancer and other extra-colonic manifestations were assessed in 897 FAP patients, 653 of whom were also investigated for APC mutations. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were computed using an unconditional multiple logistic regression model. Desmoids developed in 107 patients (11.9%), with a cumulative risk of 20.6%. Females had a significantly higher risk than males (OR = 2.1; 95% CI 1.4-3.1). Family history of desmoids (OR = 8.75; 95% CI 5.66-13.51), osteomas (OR = 2.9; 95% CI 1.8-4.8) and epidermoid cysts (OR = 1.8; 95% CI 1.1-3.2) was also significantly associated with the occurrence of disease. Subjects with APC mutations beyond codon 1444 had a 12-fold increased risk, compared with patients with mutations located upstream. Mutations beyond codon 1309 conferred a 17-fold higher risk, compared with mutations upstream codon 452. Multivariate analysis identified as independent predictors mutation beyond codon 1444 (OR = 6.2; 95% CI 2.5-15.8), family history of desmoids (OR = 5.8; 95% CI 3.1-10.6), female gender (OR = 2.1; 95% CI 1.1-3.8) and the presence of osteomas (OR = 1.9; 95% CI 1.1-3.4). Our results indicate that integrating genetic and clinical data is helpful in defining subgroups of patients at higher risk for desmoids, who may benefit from specific prevention programs.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0020-7136
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| pubmed:author |
pubmed-author:BertarioLL,
pubmed-author:D'amicoFF,
pubmed-author:EboliMM,
pubmed-author:GiaroliEE,
pubmed-author:GismondiVV,
pubmed-author:Hereditary Colorectal Tumours Registry,
pubmed-author:PierottiM AMA,
pubmed-author:RadicePP,
pubmed-author:RussoAA,
pubmed-author:SalaPP,
pubmed-author:VarescoLL
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| pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
95
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
102-7
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| pubmed:dateRevised |
2007-7-24
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| pubmed:meshHeading |
pubmed-meshheading:11241320-Adenomatous Polyposis Coli,
pubmed-meshheading:11241320-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:11241320-Adolescent,
pubmed-meshheading:11241320-Adult,
pubmed-meshheading:11241320-Age Factors,
pubmed-meshheading:11241320-Age of Onset,
pubmed-meshheading:11241320-Aged,
pubmed-meshheading:11241320-Child,
pubmed-meshheading:11241320-Child, Preschool,
pubmed-meshheading:11241320-Colorectal Neoplasms,
pubmed-meshheading:11241320-Confidence Intervals,
pubmed-meshheading:11241320-Cytoskeletal Proteins,
pubmed-meshheading:11241320-Epidermal Cyst,
pubmed-meshheading:11241320-Family Health,
pubmed-meshheading:11241320-Female,
pubmed-meshheading:11241320-Fibromatosis, Abdominal,
pubmed-meshheading:11241320-Fibromatosis, Aggressive,
pubmed-meshheading:11241320-Follow-Up Studies,
pubmed-meshheading:11241320-Genotype,
pubmed-meshheading:11241320-Humans,
pubmed-meshheading:11241320-Infant,
pubmed-meshheading:11241320-Male,
pubmed-meshheading:11241320-Middle Aged,
pubmed-meshheading:11241320-Multivariate Analysis,
pubmed-meshheading:11241320-Mutation,
pubmed-meshheading:11241320-Odds Ratio,
pubmed-meshheading:11241320-Osteoma,
pubmed-meshheading:11241320-Phenotype,
pubmed-meshheading:11241320-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:11241320-Registries,
pubmed-meshheading:11241320-Risk Factors,
pubmed-meshheading:11241320-Sex Factors,
pubmed-meshheading:11241320-Time Factors
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| pubmed:year |
2001
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| pubmed:articleTitle |
Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis.
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| pubmed:affiliation |
Department of Surgery, National Cancer Institute, Milan, Italy. bertario@istitutotumori.mi.it
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| pubmed:publicationType |
Journal Article
|