Source:http://linkedlifedata.com/resource/pubmed/id/11240076
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2001-3-12
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| pubmed:abstractText |
The study examined the validity of oral fentanyl self-administration (FSA) as a measure of the chronic nociceptive pain that develops in rats with adjuvant arthritis independently of acute noxious challenges. Arthritic rats self-administered more of a 0.008 mg/ml fentanyl solution (up to 3.4 g/rat per day) than non-arthritic controls (0.5 g/rat per day) and did so with a biphasic time course that reached peak during weeks 3 and 4 after inoculation with Mycobacterium butyricum. The time course paralleled both the disease process and the chronic pain. Continuous infusion of dexamethasone during weeks 3 and 4 via subcutaneous osmotic pumps at 0.0025-0.04 mg/rat per day disrupted the arthritic disease and decreased FSA to a level (i.e. by 65%) similar to that observed in non-arthritic rats. Continuous naloxone (2.5 mg/rat per day) decreased FSA (by 55%) in arthritic but not in non-arthritic animals. Continuous, subcutaneous infusion of fentanyl also decreased arthritic FSA in a manner that varied with dose at 0.04-0.16 mg/rat per day doses, but leveled off at 47% of controls with 0.31 mg/rat per day. The effects of continuous fentanyl on arthritic FSA occurred only with those doses and dose-dependent dynamics with which fentanyl also induced dependence in non-arthritic rats. The findings indicate that pain, rather than the rewarding or dependence-inducing action of fentanyl mediates FSA in arthritic rats. Paralleling patient-controlled analgesic drug intake, FSA offers a specific measure allowing the dynamic effects of neurobiological agents to be studied in this unique animal model of persistent nociceptive pain.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Fentanyl,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotics
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0304-3959
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
91
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
33-45
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11240076-Analgesics, Opioid,
pubmed-meshheading:11240076-Animals,
pubmed-meshheading:11240076-Arthritis,
pubmed-meshheading:11240076-Behavior, Animal,
pubmed-meshheading:11240076-Chronic Disease,
pubmed-meshheading:11240076-Fentanyl,
pubmed-meshheading:11240076-Male,
pubmed-meshheading:11240076-Naloxone,
pubmed-meshheading:11240076-Narcotic Antagonists,
pubmed-meshheading:11240076-Narcotics,
pubmed-meshheading:11240076-Nociceptors,
pubmed-meshheading:11240076-Pain,
pubmed-meshheading:11240076-Pain Measurement,
pubmed-meshheading:11240076-Palliative Care,
pubmed-meshheading:11240076-Rats,
pubmed-meshheading:11240076-Rats, Inbred Lew,
pubmed-meshheading:11240076-Reference Values,
pubmed-meshheading:11240076-Self Administration,
pubmed-meshheading:11240076-Substance-Related Disorders,
pubmed-meshheading:11240076-Time Factors
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| pubmed:year |
2001
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| pubmed:articleTitle |
Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats.
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| pubmed:affiliation |
Centre de Recherche Pierre Fabre, 17 Avenue Jean Moulin, 81106 cedex, Castres, France. francis.colpaert@pierre-fabre.com
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| pubmed:publicationType |
Journal Article
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