|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005768,
umls-concept:C0007806,
umls-concept:C0026769,
umls-concept:C0035020,
umls-concept:C0037083,
umls-concept:C0039194,
umls-concept:C0282554,
umls-concept:C0524914,
umls-concept:C0544452,
umls-concept:C0597360,
umls-concept:C1423842,
umls-concept:C1710082
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2001-3-12
|
|
pubmed:abstractText |
The expression of chemokine receptors on lymphocytes in the blood and CSF of multiple sclerosis (MS) patients was analyzed at relapse and remission. Both CD4+ and CD8+ cells in CSF at relapse were enriched for Th1-type receptors CXCR3 and CCR5 expression, and were reduced for Th2-type receptors CCR3 and CCR4 expression compared with those of the blood. CCR1 and CCR2 expressions on T cells were increased in CSF and blood, respectively. At remission, CCR5 expression, but not CXCR3 expression, was reduced in CSF CD4+ cells. A biased Th1/Th2 balance may play a critical role in active inflammation and CCR5 on CSF CD4+ cells is a good marker of the disease activity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CCR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0165-5728
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
114
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
207-12
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11240033-Adult,
pubmed-meshheading:11240033-Biological Markers,
pubmed-meshheading:11240033-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11240033-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11240033-Female,
pubmed-meshheading:11240033-Humans,
pubmed-meshheading:11240033-Male,
pubmed-meshheading:11240033-Multiple Sclerosis, Relapsing-Remitting,
pubmed-meshheading:11240033-Receptors, CCR1,
pubmed-meshheading:11240033-Receptors, CCR2,
pubmed-meshheading:11240033-Receptors, CCR4,
pubmed-meshheading:11240033-Receptors, CCR5,
pubmed-meshheading:11240033-Receptors, CXCR3,
pubmed-meshheading:11240033-Receptors, Chemokine,
pubmed-meshheading:11240033-Recurrence,
pubmed-meshheading:11240033-Remission, Spontaneous,
pubmed-meshheading:11240033-Signal Transduction,
pubmed-meshheading:11240033-Th1 Cells,
pubmed-meshheading:11240033-Th2 Cells
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling.
|
|
pubmed:affiliation |
Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryo-Machi, Aoba-ku, Sendai 980-8574, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
