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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
We have examined the chemotactic responsiveness of thymocytes to selective mu-, kappa-, and delta-opioid agonists. Our results show that developing T cells migrate in response to mu-, but not kappa- or delta-opioids. The mu-opioid response appears to be dependent on the classical mu-opioid receptor (MOR-1) since the chemotactic response is blocked by a selective mu-opioid antagonist, and is absent in thymocytes from MOR-1-deficient mice. Flow cytometric analysis of the mu-opioid responsive cells shows that these cells consist predominantly of highly immature CD4- CD8- T cells. These results represent the first demonstration of the functional expression of mu-opioid receptors by developing T cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dichloro-N-methyl-N-(2-(1-pyrrol...,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Non-Narcotic,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, D-Penicillamine (2,5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Oprm protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-80
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11240029-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-ben...,
pubmed-meshheading:11240029-Analgesics, Non-Narcotic,
pubmed-meshheading:11240029-Analgesics, Opioid,
pubmed-meshheading:11240029-Animals,
pubmed-meshheading:11240029-Cell Differentiation,
pubmed-meshheading:11240029-Cells, Cultured,
pubmed-meshheading:11240029-Chemotaxis, Leukocyte,
pubmed-meshheading:11240029-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-,
pubmed-meshheading:11240029-Enkephalin, D-Penicillamine (2,5)-,
pubmed-meshheading:11240029-Gene Expression,
pubmed-meshheading:11240029-Male,
pubmed-meshheading:11240029-Mice,
pubmed-meshheading:11240029-Mice, Inbred BALB C,
pubmed-meshheading:11240029-Mice, Inbred C57BL,
pubmed-meshheading:11240029-Mice, Knockout,
pubmed-meshheading:11240029-Receptors, Opioid, mu,
pubmed-meshheading:11240029-Specific Pathogen-Free Organisms,
pubmed-meshheading:11240029-T-Lymphocytes,
pubmed-meshheading:11240029-Thymus Gland
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pubmed:year |
2001
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pubmed:articleTitle |
Expression of functional mu-opioid receptors during T cell development.
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pubmed:affiliation |
Department of Microbiology and Immunology, The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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