Source:http://linkedlifedata.com/resource/pubmed/id/11239902
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
Noradrenergic dysfunction has been consistently implicated in depression. Much of the evidence, though, has been indirect, such as an attenuated growth hormone response to the alpha2-adrenoceptor agonist clonidine. To more directly examine central functioning of the noradrenergic system in depression, we have used [15O] H2O positron emission tomography (PET) to measure cerebral blood flow (rCBF) in combination with clonidine as a neuromodulatory probe.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3223
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
317-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11239902-Adrenergic alpha-Agonists,
pubmed-meshheading:11239902-Adult,
pubmed-meshheading:11239902-Attention,
pubmed-meshheading:11239902-Cerebrovascular Circulation,
pubmed-meshheading:11239902-Clonidine,
pubmed-meshheading:11239902-Female,
pubmed-meshheading:11239902-Human Growth Hormone,
pubmed-meshheading:11239902-Humans,
pubmed-meshheading:11239902-Prefrontal Cortex,
pubmed-meshheading:11239902-Receptors, Adrenergic, alpha,
pubmed-meshheading:11239902-Tomography, Emission-Computed
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pubmed:year |
2001
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pubmed:articleTitle |
Noradrenergic dysfunction in the prefrontal cortex in depression: an [15O] H2O PET study of the neuromodulatory effects of clonidine.
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pubmed:affiliation |
Centre for Addiction and Mental Health, Clarke Site, University of Toronto, Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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