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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
Gene delivery of biologically active molecules to the kidney may have potential therapeutic applications in renal and cardiovascular diseases. Recombinant adenovirus is one of the most efficient vectors for in vivo gene delivery. However, in vivo toxicity at the site of administration has to be evaluated for the successful use of adenovirus-mediated gene transfer. The aim of this study was to document precisely the short-term safety of different routes of intra-renal adenoviral administration and to compare their transduction efficiency.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0931-0509
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pubmed:author |
pubmed-author:AdamMM,
pubmed-author:AdnotSS,
pubmed-author:ChetboulVV,
pubmed-author:CrespeauFF,
pubmed-author:DesvauxDD,
pubmed-author:EloitMM,
pubmed-author:KlonjkowskiBB,
pubmed-author:LarouteVV,
pubmed-author:LefebvreH PHP,
pubmed-author:MaureyCC,
pubmed-author:PouchelonJ LJL,
pubmed-author:RosenbergDD
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
608-14
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11239040-Adenoviridae,
pubmed-meshheading:11239040-Animals,
pubmed-meshheading:11239040-Dogs,
pubmed-meshheading:11239040-Efficiency,
pubmed-meshheading:11239040-Gene Expression,
pubmed-meshheading:11239040-Gene Transfer Techniques,
pubmed-meshheading:11239040-Genetic Vectors,
pubmed-meshheading:11239040-Injections,
pubmed-meshheading:11239040-Kidney,
pubmed-meshheading:11239040-Kidney Cortex,
pubmed-meshheading:11239040-Kidney Tubules,
pubmed-meshheading:11239040-Male,
pubmed-meshheading:11239040-Renal Artery,
pubmed-meshheading:11239040-Safety,
pubmed-meshheading:11239040-Time Factors,
pubmed-meshheading:11239040-Transduction, Genetic,
pubmed-meshheading:11239040-Ureter,
pubmed-meshheading:11239040-beta-Galactosidase
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pubmed:year |
2001
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pubmed:articleTitle |
Short-term efficiency and safety of gene delivery into canine kidneys.
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pubmed:affiliation |
Unité de Cardiologie d'Alfort, CHU Henri-Mondor, Créteil, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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