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rdf:type |
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lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0086418,
umls-concept:C0152060,
umls-concept:C0205103,
umls-concept:C0205154,
umls-concept:C0439097,
umls-concept:C0756979,
umls-concept:C1157338,
umls-concept:C1306235,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1704259,
umls-concept:C1705241,
umls-concept:C1705987,
umls-concept:C1823153,
umls-concept:C1879547,
umls-concept:C2349976
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pubmed:issue |
6
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
Activation of V gamma 9/V delta 2 T cells by small nonprotein Ags is frequently observed after infection with various viruses, bacteria, and eukaryotic parasites. We suggested earlier that compounds synthesized by the 2-C:-methyl-D-erythritol 4-phosphate (MEP) pathway of isopentenyl pyrophosphate synthesis are responsible for the V gamma 9/V delta 2 T cell reactivity of many pathogens. Using genetically engineered Escherichia coli knockout strains, we now demonstrate that the ability of E. coli extracts to stimulate gamma delta T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-deoxy-D-xylulose 5-phosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/2-C-methylerythritol 4-phosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Aldose-Ketose Isomerases,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Erythritol,
http://linkedlifedata.com/resource/pubmed/chemical/Hemiterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Sugar Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxymethylbutenyl 4-diphosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/isopentenyl pyrophosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:AltincicekBB,
pubmed-author:BeckEE,
pubmed-author:BoronatAA,
pubmed-author:CamposNN,
pubmed-author:EbertEE,
pubmed-author:FoersterGG,
pubmed-author:Grosdemange-BilliardCC,
pubmed-author:HoefflerJ FJF,
pubmed-author:JomaaHH,
pubmed-author:MollJJ,
pubmed-author:Rodríguez-ConcepciónMM,
pubmed-author:RohmerMM
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3655-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11238603-Aldose-Ketose Isomerases,
pubmed-meshheading:11238603-Bacterial Proteins,
pubmed-meshheading:11238603-Cell Fractionation,
pubmed-meshheading:11238603-Enzymes,
pubmed-meshheading:11238603-Erythritol,
pubmed-meshheading:11238603-Escherichia coli,
pubmed-meshheading:11238603-Gene Deletion,
pubmed-meshheading:11238603-Hemiterpenes,
pubmed-meshheading:11238603-Humans,
pubmed-meshheading:11238603-Lymphocyte Activation,
pubmed-meshheading:11238603-Molecular Weight,
pubmed-meshheading:11238603-Multienzyme Complexes,
pubmed-meshheading:11238603-Organophosphorus Compounds,
pubmed-meshheading:11238603-Oxidoreductases,
pubmed-meshheading:11238603-Protein Engineering,
pubmed-meshheading:11238603-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:11238603-Signal Transduction,
pubmed-meshheading:11238603-Sugar Phosphates,
pubmed-meshheading:11238603-T-Lymphocyte Subsets
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pubmed:year |
2001
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pubmed:articleTitle |
Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis.
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pubmed:affiliation |
Jomaa Pharmaka GmbH, Giessen, Germany. boran.altincicek@biochemie.med.uni-giessen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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