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rdf:type |
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lifeskim:mentions |
umls-concept:C0023688,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0086418,
umls-concept:C0162638,
umls-concept:C0333516,
umls-concept:C0385242,
umls-concept:C1332714,
umls-concept:C1336646,
umls-concept:C1511545,
umls-concept:C1880177
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pubmed:issue |
5
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
Apoptosis is a key for CD4+ T cell destruction in HIV-1-infected patients. In this study, human peripheral blood lymphocyte (PBL)-transplanted nonobese diabetic (NOD)-severe combined immunodeficient (SCID) (hu-PBL-NOD-SCID) mice were used to examine in vivo apoptosis after HIV-1 infection. As the hu-PBL-NOD-SCID mouse model allowed us to see extensive infection with HIV-1 and to analyze apoptosis in human cells in combination with immunohistological methods, we were able to quantify the number of apoptotic cells with HIV-1 infection. As demonstrated by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), massive apoptosis was predominantly observed in virus-uninfected CD4+ T cells in the spleens of HIV-1-infected mice. A combination of TUNEL and immunostaining for death-inducing tumor necrosis factor (TNF) family molecules indicated that the apoptotic cells were frequently found in conjugation with TNF-related apoptosis-inducing ligand (TRAIL)-expressing CD3+CD4+ human T cells. Administration of a neutralizing anti-TRAIL mAb in HIV-1-infected mice markedly inhibited the development of CD4+ T cell apoptosis. These results suggest that a large number of HIV-1-uninfected CD4+ T cells undergo TRAIL-mediated apoptosis in HIV-infected lymphoid organs.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-10072506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-10209050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-10224285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-10395688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-10415024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-10502402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-10590149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-10676636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-1346269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-1352911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-1545126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-2665081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-4374474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-6317754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-7529365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-7539037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-7539892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-7585008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-7730654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-7816094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8096068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8415751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8455722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8480181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8523526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8652808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8777713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8781430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8838700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-8918700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9032379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9159165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9242610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9242611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9274823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9334376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9343202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9485194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9794371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9797726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11238596-9872319
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf10 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
pubmed-author:InagakiYY,
pubmed-author:ItoMM,
pubmed-author:KayagakiNN,
pubmed-author:KoyanagiYY,
pubmed-author:MaedaNN,
pubmed-author:MisawaNN,
pubmed-author:MiuraYY,
pubmed-author:MizusawaHH,
pubmed-author:TanakaYY,
pubmed-author:YagitaHH,
pubmed-author:YamamotoNN
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
193
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
651-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11238596-Humans,
pubmed-meshheading:11238596-Animals,
pubmed-meshheading:11238596-Mice,
pubmed-meshheading:11238596-Spleen,
pubmed-meshheading:11238596-Lymphocyte Transfusion,
pubmed-meshheading:11238596-Disease Models, Animal,
pubmed-meshheading:11238596-Crosses, Genetic,
pubmed-meshheading:11238596-Graft Survival,
pubmed-meshheading:11238596-Antibodies, Monoclonal,
pubmed-meshheading:11238596-Apoptosis,
pubmed-meshheading:11238596-Membrane Glycoproteins,
pubmed-meshheading:11238596-Tumor Necrosis Factor-alpha
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