Source:http://linkedlifedata.com/resource/pubmed/id/11238090
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2001-3-12
|
| pubmed:abstractText |
The mechanism of lymphomagenesis of hepatitis C virus (HCV)-related B-cell lymphoma is unknown. Recently, it has been suggested that HCV may induce B-cell clonal proliferation and t(14;18) translocation in patients chronically infected with the virus. Thus, this study investigated the effect of antiviral treatment on immunoglobulin heavy-chain gene (IgH) rearrangement and t(14;18) translocation in HCV infected patients. Twenty-nine patients with chronic HCV infection were studied in whom IgH rearrangement and/or t(14;18) translocation were previously detected. The IgH rearrangement (FR3/JH) and t(14;18) translocation (MBR bcl2-JH) were detected in peripheral blood mononuclear cells by polymerase chain reaction. Fifteen of 29 patients (8 with IgH rearrangement, 6 with t(14;18) translocation, and 1 with both) were treated with either interferon-alpha or by combination therapy with interferon and ribavirin for 6 to 12 months. IgH rearrangement became negative in 7 of 9 treated patients compared with only 1 of 8 of nontreated patients (P <.02). The t(14;18) translocation became negative in 6 of 7 treated patients compared with 1 of 6 nontreated patients (P =.03). Disappearance of IgH rearrangement or t(14;18) translocation was strongly associated with virologic response to treatment. Two t(14;18)+ patients developed B-cell lymphoma during follow-up. Antiviral treatment appears to be effective in eliminating the clonal proliferation of B cells in patients with chronic HCV infection and may prevent the subsequent development of lymphoma. The mechanism can be related to a direct effect of interferon-alpha on the proliferating clone or to an indirect effect by eradicating the antigenic stimulus.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0006-4971
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
97
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1555-9
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| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11238090-Adult,
pubmed-meshheading:11238090-Aged,
pubmed-meshheading:11238090-Antiviral Agents,
pubmed-meshheading:11238090-B-Lymphocytes,
pubmed-meshheading:11238090-Cell Division,
pubmed-meshheading:11238090-Chromosomes, Human, Pair 14,
pubmed-meshheading:11238090-Chromosomes, Human, Pair 18,
pubmed-meshheading:11238090-Drug Therapy, Combination,
pubmed-meshheading:11238090-Female,
pubmed-meshheading:11238090-Gene Rearrangement,
pubmed-meshheading:11238090-Genes, bcl-2,
pubmed-meshheading:11238090-Hepatitis C, Chronic,
pubmed-meshheading:11238090-Humans,
pubmed-meshheading:11238090-Immunoglobulin Heavy Chains,
pubmed-meshheading:11238090-Interferon-alpha,
pubmed-meshheading:11238090-Lymphoma, B-Cell,
pubmed-meshheading:11238090-Male,
pubmed-meshheading:11238090-Middle Aged,
pubmed-meshheading:11238090-Ribavirin,
pubmed-meshheading:11238090-Translocation, Genetic
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection.
|
| pubmed:affiliation |
Liver Unit and the Department of Internal Medicine A, and the Institute of Hematology, Bnai Zion Medical Center, Haifa, Israel.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|