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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-3-12
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pubmed:databankReference |
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pubmed:abstractText |
Hypoxia-inducible factor 1 (HIF-1) is composed of HIF-1alpha and arylhydrocarbon nuclear receptor translocator (ARNT), which belong to the basic-helix-loop-helix-Per/ARNT/Sim (bHLH-PAS) family of transcription factors. HIF plays key roles in oxygen homeostasis and embryonic cardiovascular development. In this study, we have cloned cDNAs encoding the chick HIF-1alpha from cultured embryonic ventricular myocytes (CEVM) and then examined its expression in various embryonic tissues. The deduced amino acid sequence of the chick HIF-1alpha cDNA showed 79% identity with that of the human HIF-1alpha cDNA. In contrast, sequence homology between the chick HIF-1alpha and endothelial PAS protein 1 (EPAS1), another member of the bHLH-PAS proteins, was only low (49%). HIF-1alpha mRNA was expressed abundantly in CEVM, but scarcely in the liver, which was quite different from expression pattern of EPAS1 mRNA. These data suggest that HIF-1alpha may be involved in embryonic cardiovascular development. HIF-1alpha and EPAS1 may play distinct roles during developmental stages.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/endothelial PAS domain-containing...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
281
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1057-62
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pubmed:dateRevised |
2007-4-11
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pubmed:meshHeading |
pubmed-meshheading:11237772-Amino Acid Sequence,
pubmed-meshheading:11237772-Animals,
pubmed-meshheading:11237772-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:11237772-Blotting, Northern,
pubmed-meshheading:11237772-Chick Embryo,
pubmed-meshheading:11237772-Cloning, Molecular,
pubmed-meshheading:11237772-DNA, Complementary,
pubmed-meshheading:11237772-DNA-Binding Proteins,
pubmed-meshheading:11237772-Gene Expression Regulation, Developmental,
pubmed-meshheading:11237772-Heart Ventricles,
pubmed-meshheading:11237772-Hypoxia-Inducible Factor 1,
pubmed-meshheading:11237772-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:11237772-Molecular Sequence Data,
pubmed-meshheading:11237772-Nuclear Proteins,
pubmed-meshheading:11237772-RNA, Messenger,
pubmed-meshheading:11237772-Sequence Alignment,
pubmed-meshheading:11237772-Sequence Homology, Amino Acid,
pubmed-meshheading:11237772-Tissue Distribution,
pubmed-meshheading:11237772-Trans-Activators,
pubmed-meshheading:11237772-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Cloning of hypoxia-inducible factor 1alpha cDNA from chick embryonic ventricular myocytes.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. toshitak-tky@umin.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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