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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
HSV-1 ICP34.5 mutants can slow progression of preformed tumors in rodent models. However, the current models available for study are limited due to the lack of a syngenic, low-immunogenic tumor model susceptible to HSV-1. Thus we have developed a new model to determine the role of the immune response in viral-mediated tumor destruction. The human herpesvirus entry (Hve) receptors (HveA, HveB, and HveC) and a control plasmid were transfected into B78H1 murine melanoma cells. Transfection of HveA and HveC conferred sensitivity to HSV-1 to these cells. A10 (HveA), C10 (HveC), and control cells were able to form tumors reproducibly in vivo. The transfection of the receptors into B78H1 cells did not induce a detectable in vivo immunogenicity to the tumors. Finally, A10 and C10 tumor-bearing mice treated with HSV-1 1716 had significant prolongation of survival compared to mock-treated mice. These data suggest that A10 and C10 will be useful as in vivo models for studying the role of the immune response in viral-mediated tumor destruction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1525-0016
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
160-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11237672-Animals,
pubmed-meshheading:11237672-Cell Line,
pubmed-meshheading:11237672-Cells, Cultured,
pubmed-meshheading:11237672-Cercopithecus aethiops,
pubmed-meshheading:11237672-Disease Models, Animal,
pubmed-meshheading:11237672-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11237672-Female,
pubmed-meshheading:11237672-Herpesvirus 1, Human,
pubmed-meshheading:11237672-Melanoma, Experimental,
pubmed-meshheading:11237672-Mice,
pubmed-meshheading:11237672-Mice, Inbred C57BL,
pubmed-meshheading:11237672-Neoplasm Transplantation,
pubmed-meshheading:11237672-Plasmids,
pubmed-meshheading:11237672-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:11237672-Receptors, Tumor Necrosis Factor, Member 14,
pubmed-meshheading:11237672-Receptors, Virus,
pubmed-meshheading:11237672-Time Factors,
pubmed-meshheading:11237672-Transfection,
pubmed-meshheading:11237672-Tumor Cells, Cultured,
pubmed-meshheading:11237672-Vero Cells
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pubmed:year |
2001
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pubmed:articleTitle |
Development of a syngenic murine B16 cell line-derived melanoma susceptible to destruction by neuroattenuated HSV-1.
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pubmed:affiliation |
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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