| pubmed-article:1123738 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1123738 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:1123738 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:1123738 | lifeskim:mentions | umls-concept:C0017136 | lld:lifeskim |
| pubmed-article:1123738 | lifeskim:mentions | umls-concept:C0033727 | lld:lifeskim |
| pubmed-article:1123738 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1123738 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1123738 | pubmed:dateCreated | 1975-6-29 | lld:pubmed |
| pubmed-article:1123738 | pubmed:abstractText | 1. A new preparation of gastric mucosa isolated from new-born piglets is described. The piglet gastric mucosa was easily separated from the serosal muscle layers by a "blistering" technique which appeared to cause minimal trauma to the tissue and which allowed extended study in vitro in a suitable chamber. Normal resting p.d. was approximately minus 30 mV (mucosal side negative with respect to serosal side), resistance about 100 omega. cm-2 and H+ secretion was absent or occurred at very low rates (0-1mu-equiv/cm-2. hr). 2. Maximally stimulating doses of histamine (1-6 times 10-5 M) caused H+ secretion to increase (up to 15 muequiv/cm-2. hr), p.d. to increase and resistance to decrease. A close correlation was observed between the increase in H+ secretion and decrease in transmucosal resistance. The threshold dose of histamine appeared to be 10-8 M; concentrations 10-4 M and higher reduced H+ secretion somewhat. 3. Pentagastrin ( 10-9-10-7 M) and acetylcholine (10-7-10-5 M) did not significantly stimulate the piglet gastric mucosa. Pentagastrin concentrations above 4 times 10-6 M reversibly inhibited H+ secretion of histamine-stimulated mucosa. High concentrations of acetylcholine (above 4 times 10-4 M) did not affect histamine-stimulated H+ secretion, but a significant reduction in p.d. was observed. 4. This investigation demonstrates the utility of the piglet gastric mucosa for in vitro studies of the mechanism H+ secretion and the action of secretagogues. From a consideration of such factors as the thinness of tissue and ease of preparation it is suggested that neonatal animals may represent a good source of in vitro mammalian gastric tissue. | lld:pubmed |
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| pubmed-article:1123738 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1123738 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1123738 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1123738 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1123738 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1123738 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1123738 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:1123738 | pubmed:author | pubmed-author:ForteJ GJG | lld:pubmed |
| pubmed-article:1123738 | pubmed:author | pubmed-author:MachenT ETE | lld:pubmed |
| pubmed-article:1123738 | pubmed:author | pubmed-author:ForteT MTM | lld:pubmed |
| pubmed-article:1123738 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1123738 | pubmed:volume | 244 | lld:pubmed |
| pubmed-article:1123738 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1123738 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1123738 | pubmed:pagination | 15-31 | lld:pubmed |
| pubmed-article:1123738 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1123738 | pubmed:meshHeading | pubmed-meshheading:1123738-... | lld:pubmed |
| pubmed-article:1123738 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:1123738 | pubmed:articleTitle | Histamine-stimulated hydrogen ion secretion by in vitro piglet gastric mucosa. | lld:pubmed |
| pubmed-article:1123738 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1123738 | pubmed:publicationType | In Vitro | lld:pubmed |
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