Linked Life Data

11236714

Source:http://linkedlifedata.com/resource/pubmed/id/11236714

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-3-9
pubmed:abstractText
Studies of C. elegans vulval development provide insights into the process of pattern formation during animal development. The invariant pattern of vulval precursor cell fates is specified by the integration of at least two signaling systems. Recent findings suggest that multiple, partially redundant mechanisms are involved in patterning the vulval precursor cells. The inductive signal activates the LET-60/RAS signaling pathway and induces the 1 degree fate, whereas the lateral signal mediated by LIN-12/Notch is required for specification of the 2 degrees fate. Several regulatory pathways antagonize the RAS signaling pathway and specify the non-vulval 3 degrees fate in the absence of induction. The temporal and spatial regulation of VPC competence and production of the inductive and the lateral signal are precisely coordinated to ensure the wild-type vulval pattern.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0070-2153
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-220
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Pattern formation during C. elegans vulval induction.
pubmed:affiliation
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't