Source:http://linkedlifedata.com/resource/pubmed/id/11234900
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-3-7
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| pubmed:abstractText |
Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2) is an important target for preventing epithelial malignancies. Little is known, however, about the expression of COX-2 in gynecological malignancies. By immunoblot analysis, COX-2 was detected in 12 of 13 cases of cervical cancer but was undetectable in normal cervical tissue. Immunohistochemistry revealed COX-2 in malignant epithelial cells. COX-2 was also expressed in cervical intraepithelial neoplasia. The mechanism by which COX-2 is up-regulated in cervical cancer is unknown. Because the epidermal growth factor (EGF) receptor is commonly overexpressed in cervical cancer, we investigated whether EGF could induce COX-2 in cultured human cervical carcinoma cells. Treatment with EGF markedly induced COX-2 protein, COX-2 mRNA, and stimulated COX-2 promoter activity. The induction of COX-2 by EGF was suppressed by inhibitors of tyrosine kinase activity, phosphatidylinositol 3-kinase, mitogen-activated protein kinase kinase, and p38 mitogen-activated protein kinase. Moreover, overexpressing dominant-negative forms of extracellular signal-regulated kinase 1, c-Jun NH2-terminal kinase, p38, and c-Jun blocked EGF-mediated induction of COX-2 promoter activity. Taken together, these findings suggest that deregulation of the EGF receptor signaling pathway may lead to enhanced COX-2 expression in cervical cancer.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1078-0432
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
429-34
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:11234900-Adenocarcinoma,
pubmed-meshheading:11234900-Blotting, Northern,
pubmed-meshheading:11234900-Blotting, Western,
pubmed-meshheading:11234900-Carcinoma, Adenosquamous,
pubmed-meshheading:11234900-Carcinoma, Squamous Cell,
pubmed-meshheading:11234900-Cyclooxygenase 2,
pubmed-meshheading:11234900-Female,
pubmed-meshheading:11234900-Genes, erbB-1,
pubmed-meshheading:11234900-Humans,
pubmed-meshheading:11234900-Immunoenzyme Techniques,
pubmed-meshheading:11234900-Isoenzymes,
pubmed-meshheading:11234900-Membrane Proteins,
pubmed-meshheading:11234900-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11234900-Plasmids,
pubmed-meshheading:11234900-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:11234900-RNA, Messenger,
pubmed-meshheading:11234900-Sarcoma,
pubmed-meshheading:11234900-Signal Transduction,
pubmed-meshheading:11234900-Tumor Cells, Cultured,
pubmed-meshheading:11234900-Uterine Cervical Neoplasms
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| pubmed:year |
2001
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| pubmed:articleTitle |
Cyclooxygenase-2 is overexpressed in human cervical cancer.
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| pubmed:affiliation |
Department of Medicine, New York Presbyterian Hospital-Cornell, New York 10021, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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