Linked Life Data

11233756

Source:http://linkedlifedata.com/resource/pubmed/id/11233756

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-3-6
pubmed:abstractText
The interaction between astrocytes and neurons is examined from the standpoint of glutamate and glutathione (GSH) metabolism. These examples are outlined to provoke a reformulation of concepts of the inter-dependence between these 2 cell types, not only in terminating excitotoxicity, but also in assuring proper energetics and neuromodulation by astrocytic removal of glutamate via the astrocyte-specific glutamate transporters, GLT1 and GLAST. In addition, the role of astrocytes in the synthesis of neuronal GSH is detailed. The neuron-astrocyte interaction permits widely divergent aspects of brain energetics and modulation, and undoubtedly brain pathology where the functional unit is altered. Testing the developmental effects of compounds on this interaction is warranted and likely to establish the mechanisms by which it is compromised in a variety of disease states.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0161-813X
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1101-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Neuron-astrocyte interactions: implications for cellular energetics and antioxidant levels.
pubmed:affiliation
Department of Physiology and Pharmacology, and Interdisciplinary Program in Neuroscience, Wake Forest University School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1083, USA. maschner@wfubmc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review