Linked Life Data

1123342

Source:http://linkedlifedata.com/resource/pubmed/id/1123342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1975-7-7
pubmed:abstractText
Bis(monoacylglyceryl)phosphate is present in trace quantities in normal liver where it represents smaller than 1 percent of total liver phospholipids. This compound is of considerable interest since its level can be greatly increased in certain lipidoses, either of a genetic nature or caused by drugs. Biosynthesis of bis(monoacylglyceryl)P in vitro has not previously been demonstrated. This paper reports the enzymatic formation of bis(monoacylglyceryl)P and acylphosphatidylglycerol as minor products from cytidine diphosphate diglyceride and radioactive sn-glycerol-3-P using a crude mitochondrial fraction from normal rat liver; phosphatidylglycerol was the principal product. Evidence is also presented which shows the enzymatic formation of acylphosphatidylglycerol and bis(monoacylglyceryl)P from [1',3'-14C]phosphatidylglycerol by a crude rat liver mitochondrial preparation in vitro. The structures of the radioactive bis(monoacylglyceryl)P and acylphosphatidylglycerol were tentatively established by thin layer chromatography, and chromatography of the products of mild alkaline hydrolysis and acetolysis. Radioactive acylphosphatidylglycerol was stoichiometrically converted to bis(monoacylglyceryl)P by treatment with bee venom phospholipase A, providing additional evidence for the structure of acylphosphatidylglycerol and bis(monoacylglyceryl)P.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
250
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3297-302
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Biosynthesis of bis(monoacylglyceryl)phosphate and acylphosphatidylglycerol in rat liver mitochondrial.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.