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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-3-5
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pubmed:abstractText |
Signal transduction for cardiac muscle contraction is regulated by the Ca2+-induced Ca2+-release mechanism. Redox reactions by biological oxidants and antioxidants have been shown to alter the kinetics of Ca2+-induced Ca2+ release. We postulate that altered kinetics of Ca2+-induced Ca2+ release may divert the contractile pool of Ca2+ to elicit excitation-transcription coupling. We provide evidence that redox reactions regulate excitation-transcription coupling by showing that membrane depolarization may activate the GATA4 transcription factor only when the cells are pretreated with hydrogen peroxide. Therefore, redox regulation of the ryanodine receptor may serve as a mechanism to determine whether the contractile pool of Ca2+ should signal gene transcription during excitation-contraction coupling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GATA4 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Ryanodine Receptor Calcium Release...,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/W 7
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pubmed:status |
MEDLINE
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pubmed:issn |
1523-0864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-71
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11232602-Action Potentials,
pubmed-meshheading:11232602-Animals,
pubmed-meshheading:11232602-Antioxidants,
pubmed-meshheading:11232602-Calcium Signaling,
pubmed-meshheading:11232602-DNA-Binding Proteins,
pubmed-meshheading:11232602-GATA4 Transcription Factor,
pubmed-meshheading:11232602-Gene Expression Regulation,
pubmed-meshheading:11232602-Glutathione,
pubmed-meshheading:11232602-Hydrogen Peroxide,
pubmed-meshheading:11232602-Models, Biological,
pubmed-meshheading:11232602-Muscle Proteins,
pubmed-meshheading:11232602-Myocardial Contraction,
pubmed-meshheading:11232602-Myocardium,
pubmed-meshheading:11232602-Oxidants,
pubmed-meshheading:11232602-Oxidation-Reduction,
pubmed-meshheading:11232602-Patch-Clamp Techniques,
pubmed-meshheading:11232602-Rats,
pubmed-meshheading:11232602-Reactive Oxygen Species,
pubmed-meshheading:11232602-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:11232602-Sarcoplasmic Reticulum,
pubmed-meshheading:11232602-Sulfonamides,
pubmed-meshheading:11232602-Transcription, Genetic,
pubmed-meshheading:11232602-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Redox regulation of cardiac muscle calcium signaling.
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pubmed:affiliation |
Institute for Cardiovascular Sciences and Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA. moradm@gunet.georgetown.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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