Linked Life Data

11231924

Source:http://linkedlifedata.com/resource/pubmed/id/11231924

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-3-20
pubmed:abstractText
Infectious agents may be involved in atherothrombogenesis. The potential pathogenic pathway, however, remains unclear. We investigated the association between various infectious agents and lipoproteins known to have an atherogenic effect. We recruited 470 healthy blood donors and 238 patients with angiographically proven coronary heart disease (CHD), aged 40 to 68 years. Seropositivity to Chlamydia pneumoniae (CP), chlamydial lipopolysaccharide, and cytomegalovirus (CMV) was determined; infection with Helicobacter pylori (HP) was assessed by using the [(13)C]urea breath test. In all subjects, total cholesterol, high density lipoprotein (HDL) cholesterol, lipoprotein(a), and various apolipoproteins (apos) were determined. In unadjusted analysis, mean HDL cholesterol concentration was significantly decreased in HP-positive healthy subjects (1.36 vs 1.44 mmol/L, P=0.006) compared with HP-negative subjects. The HDL cholesterol to total cholesterol ratio was significantly decreased in HP-positive (0.259 vs 0.276, P=0.01) and CP-seropositive (0.266 vs 0.280, P=0.04) healthy subjects compared with (sero)negatives. Mean apoAI levels were significantly lower in HP-positive healthy subjects (1.46 vs 1.51 g/L, P=0.03) and in CMV-positive healthy subjects (1.47 vs 1.52 g/L, P=0.01) compared with (sero)negative subjects. After multivariable adjustment by means of linear regression analysis, only the association between HP infection and decreased HDL cholesterol (P=0.002), decreased HDL cholesterol to total cholesterol ratio (P:=0.005), decreased apoAI (P=0.02), and increased apoB (P=0.02) persisted and remained significant. There was no independent association between other lipoproteins and serological markers of CP or CMV infection. Current infection with HP, but not seropositivity to CP or CMV, was associated with an atherogenic, modified lipid profile. These lipid alterations could explain, at least in part, the reported weak association between chronic HP infection and atherosclerotic diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1524-4636
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11231924-Adult, pubmed-meshheading:11231924-Aged, pubmed-meshheading:11231924-Antibodies, Bacterial, pubmed-meshheading:11231924-Antibodies, Viral, pubmed-meshheading:11231924-Apolipoproteins, pubmed-meshheading:11231924-Arteriosclerosis, pubmed-meshheading:11231924-Chlamydophila Infections, pubmed-meshheading:11231924-Chlamydophila pneumoniae, pubmed-meshheading:11231924-Cholesterol, HDL, pubmed-meshheading:11231924-Cholesterol, LDL, pubmed-meshheading:11231924-Coronary Disease, pubmed-meshheading:11231924-Cytomegalovirus, pubmed-meshheading:11231924-Cytomegalovirus Infections, pubmed-meshheading:11231924-Female, pubmed-meshheading:11231924-Helicobacter Infections, pubmed-meshheading:11231924-Helicobacter pylori, pubmed-meshheading:11231924-Humans, pubmed-meshheading:11231924-Immunoglobulin A, pubmed-meshheading:11231924-Immunoglobulin G, pubmed-meshheading:11231924-Immunoglobulin M, pubmed-meshheading:11231924-Lipids, pubmed-meshheading:11231924-Lipoproteins, pubmed-meshheading:11231924-Male, pubmed-meshheading:11231924-Middle Aged, pubmed-meshheading:11231924-Multivariate Analysis
pubmed:year
2001
pubmed:articleTitle
Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile.
pubmed:affiliation
Department of Internal Medicine II-Cardiology, University of Ulm, Ulm, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't