|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2001-3-20
|
|
pubmed:abstractText |
Cardiovascular diseases are the leading cause of death in the Western World, especially in the elder population. One pathophysiological component of cardiovascular disease is myocardial fibrosis, primarily derived from cardiac fibroblasts. Here we investigated the regulation of proliferation of fibroblasts from hearts of adult rats by platelet derived growth factor AA (PDGF-AA).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Akt1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor A,
http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor BB
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0008-6363
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
731-40
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:11230972-Animals,
pubmed-meshheading:11230972-Blotting, Northern,
pubmed-meshheading:11230972-Blotting, Western,
pubmed-meshheading:11230972-Cell Aging,
pubmed-meshheading:11230972-Cell Division,
pubmed-meshheading:11230972-Depression, Chemical,
pubmed-meshheading:11230972-Fibroblasts,
pubmed-meshheading:11230972-Fibrosis,
pubmed-meshheading:11230972-Male,
pubmed-meshheading:11230972-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:11230972-Myocardium,
pubmed-meshheading:11230972-Platelet-Derived Growth Factor,
pubmed-meshheading:11230972-Protein Binding,
pubmed-meshheading:11230972-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11230972-Proto-Oncogene Proteins,
pubmed-meshheading:11230972-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:11230972-Rats,
pubmed-meshheading:11230972-Rats, Wistar,
pubmed-meshheading:11230972-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:11230972-Reverse Transcriptase Polymerase Chain Reaction
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation.
|
|
pubmed:affiliation |
Institut für Klinische Biochemie and Pathobiochemie, Versbacher Str. 5, D-97078, Würzburg, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
