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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-3-14
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pubmed:abstractText |
The proportion of acyclovir (ACV)-resistant herpes simplex virus (HSV) isolates in clinical specimens and laboratory isolates was determined. HSV isolates in clinical specimens and laboratory isolates were cultured in the absence or presence of 5 microg of ACV per ml. The frequency of ACV-resistant HSV was calculated as (average virus titer in the wells with ACV)/(average virus titer in the wells without ACV). The mutation frequency of HSV type 1 isolates in clinical samples (directly from patient lesions) was 7.5 x 10(-4) +/- 2.5 x 10(-4) (mean +/- standard error), and that of HSV type 2 isolates was 15.0 x 10(-4) +/- 4.6 x 10(-4). The mutation frequencies of isolates derived in the laboratory from these clinical samples were very similar. Similarly, the 50% inhibitory concentrations for isolates in clinical samples and laboratory isolates were identical. The frequencies of ACV-resistant HSV types 1 and 2 were in a narrow range of 7.5 x 10(-4) to 15.0 x 10(-4) among isolates in clinical specimens and did not change for laboratory-derived pools of viral isolates.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-10817703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-1315366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-1329640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-202961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-2155570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-3025148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-6246531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-6246532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-6275267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-6285722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-6289742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-6320535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-7835698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-9419192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-9559798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11230403-9697707
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
913-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11230403-Acyclovir,
pubmed-meshheading:11230403-Antiviral Agents,
pubmed-meshheading:11230403-Drug Resistance, Microbial,
pubmed-meshheading:11230403-Herpes Simplex,
pubmed-meshheading:11230403-Humans,
pubmed-meshheading:11230403-Laboratories,
pubmed-meshheading:11230403-Microbial Sensitivity Tests,
pubmed-meshheading:11230403-Mutation,
pubmed-meshheading:11230403-Prevalence,
pubmed-meshheading:11230403-Simplexvirus,
pubmed-meshheading:11230403-Viral Plaque Assay,
pubmed-meshheading:11230403-Virion,
pubmed-meshheading:11230403-Virology
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pubmed:year |
2001
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pubmed:articleTitle |
Frequency of acyclovir-resistant herpes simplex virus in clinical specimens and laboratory isolates.
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pubmed:affiliation |
Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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